4',7-Dihydroxyflavone

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4',7-Dihydroxyflavone
Chemical structure of 4',7-dihydroxyflavone.
Names
IUPAC name
7-Hydroxy-2-(4-hydroxyphenyl)chromen-4-one
Other names
7,4'-Dihydroxyflavone
Identifiers
2196-14-7
ChEBI CHEBI:29503
ChemSpider 4445298
Jmol 3D model Interactive image
PubChem 5282073
Properties
C15H10O4
Molar mass 254.24 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

4',7-Dihydroxyflavone is a flavone. It is found in Medicago truncatula in relation with the root nodulation symbiont Sinorhizobium meliloti[1] or in seeds of Sophora viciifolia.[2]

Like many other flavonoids, 4',7-dihydroxyflavone has been found to possess activity at the opioid receptors.[3] Specifically, it acts as an antagonist of the μ-opioid receptor and, with lower affinity, of the κ- and δ-opioid receptors.[3]

See also[edit]

  • Pratol (7-hydroxy-4-methoxyflavone) is the O-methylated form of the molecule.

References[edit]

  1. ^ Zhang, Juan; Subramanian, Senthil; Stacey, Gary; Yu, Oliver (2009). "Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti". The Plant Journal. 57 (1): 171–83. doi:10.1111/j.1365-313X.2008.03676.x. PMID 18786000. 
  2. ^ Wang, X; Li, J; Wei, L; Ohmiya, S (1996). "Flavone constituents in the seeds of Sophora vicii folia Hance". Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (in Chinese). 21 (3): 165–6, 191. PMID 9206257. 
  3. ^ a b Katavic PL, Lamb K, Navarro H, Prisinzano TE (August 2007). "Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships". J. Nat. Prod. 70 (8): 1278–82. doi:10.1021/np070194x. PMC 2265593Freely accessible. PMID 17685652. 


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