JWH-030

JWH-030
Identifiers
	IUPAC name naphthalen-1-yl-(1-pentylpyrrol- 3-yl)methanone;
CAS Number	162934-73-8
PubChem (CID)	9971539
ChemSpider	8147131
ChEMBL	CHEMBL71810
Chemical and physical data
Formula	C20H21NO
Molar mass	291.386 g/mol
3D model (Jmol)	Interactive image
	SMILES CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12 ;
	InChI InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3 ; Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N ;
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JWH-030 is a research chemical which is a cannabinoid receptor agonist.^[1] It has analgesic effects and is used in scientific research.^[2] It is a partial agonist at CB₁ receptors, with a Ki of 87nM, making it roughly half the potency of THC.^[3] It was discovered and named after Dr. John W. Huffman.

References[edit]

^ Lainton JAH, Huffman JW, Martin BR, Compton DR. Tetrahedron Letters. 1995; 36:1401.
^ Pertwee RG, Griffin, G, Lainton JAH, Huffman JW. European Journal of Pharmacology. 1995; 284:241.
^ Griffin, G.; Atkinson, P. J.; Showalter, V. M.; Martin, B. R.; Abood, M. E. (1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-35Sthio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 553–560. PMID 9580597.

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[1] Lainton JAH, Huffman JW, Martin BR, Compton DR. Tetrahedron Letters. 1995; 36:1401.

[2] Pertwee RG, Griffin, G, Lainton JAH, Huffman JW. European Journal of Pharmacology. 1995; 284:241.

[3] Griffin, G.; Atkinson, P. J.; Showalter, V. M.; Martin, B. R.; Abood, M. E. (1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-35Sthio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 553–560. PMID 9580597.

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[2]

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JWH-030

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Identifiers

IUPAC name naphthalen-1-yl-(1-pentylpyrrol- 3-yl)methanone
CAS Number	162934-73-8^Y
PubChem (CID)	9971539
ChemSpider	8147131
ChEMBL	CHEMBL71810
Chemical and physical data
Formula	C₂₀H₂₁NO
Molar mass	291.386 g/mol
3D model (Jmol)	Interactive image
SMILES CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12
InChI InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3 Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N
(verify)