Reversine
From Wikipedia, the free encyclopedia
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Names | |
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IUPAC name
N'-cyclohexyl-N-(4-morpholinophenyl)-7H-purine-2,6-diamine
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Identifiers | |
656820-32-5 ![]() |
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3D model (Jmol) | Interactive image |
ChEBI | CHEBI:CHEBI:70723 ![]() |
ChemSpider | 182286 ![]() |
ECHA InfoCard | 100.164.070 |
MeSH | C484369 |
PubChem | 210332 |
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Properties | |
C21H27N7O | |
Molar mass | 393.48538 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
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This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (November 2015) (Learn how and when to remove this template message) |
Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation.
It also has the potential to induce selectively cell death of cancer cells.
Reversine is known to act as an antagonist of the adenosine A3 receptor.
References[edit]
- Chen, Shuibing; Zhang, Qisheng; Wu, Xu; Schultz, Peter G.; Ding, Sheng (2004). "Dedifferentiation of Lineage-Committed Cells by a Small Molecule". Journal of the American Chemical Society. 126 (2): 410–1. doi:10.1021/ja037390k. PMID 14719906.
- Chen, S.; Takanashi, S.; Zhang, Q.; Xiong, W.; Zhu, S.; Peters, E. C.; Ding, S.; Schultz, P. G. (2007). "Reversine increases the plasticity of lineage-committed mammalian cells". Proceedings of the National Academy of Sciences. 104 (25): 10482–7. Bibcode:2007PNAS..10410482C. doi:10.1073/pnas.0704360104. PMC 1965539
. PMID 17566101.
- Henry, Celia (January 5, 2004). "Cellular U-Turn". Chemical and Engineering News. 82 (1): 9. doi:10.1021/cen-v082n001.p009.
- Piccoli, Marco; Palazzolo, Giacomo; Conforti, Erika; Lamorte, Giuseppe; Papini, Nadia; Creo, Pasquale; Fania, Chiara; Scaringi, Raffaella; Bergante, Sonia; Tringali, Cristina; Roncoroni, Leda; Mazzoleni, Stefania; Doneda, Luisa; Galli, Rossella; Venerando, Bruno; Tettamanti, Guido; Gelfi, Cecilia; Anastasia, Luigi (2012). "The synthetic purine reversine selectively induces cell death of cancer cells". Journal of Cellular Biochemistry. 113 (10): 3207–17. doi:10.1002/jcb.24197. PMID 22615034.
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