Diphenylpyraline
From Wikipedia, the free encyclopedia
Jump to: navigation, search
![]() |
|
Clinical data | |
---|---|
AHFS/Drugs.com | International Drug Names |
Routes of administration |
Oral, Topical |
ATC code | R06AA07 (WHO) |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Biological half-life | 24–40 hours[1] |
Identifiers | |
|
|
Synonyms | 4-(diphenylmethoxy)-1-methyl-piperidine |
CAS Number | 147-20-6 ![]() |
PubChem (CID) | 3103 |
IUPHAR/BPS | 7165 |
DrugBank | DB01146 ![]() |
ChemSpider | 2992 ![]() |
UNII | 33361OE3AV ![]() |
KEGG | D07862 ![]() |
ChEBI | CHEBI:59788 ![]() |
ChEMBL | CHEMBL1492 ![]() |
ECHA InfoCard | 100.005.170 |
Chemical and physical data | |
Formula | C19H23NO |
Molar mass | 281.392 g/mol |
3D model (Jmol) | Interactive image |
|
|
|
|
(verify) |
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.[2][3][4] It is marketed in Europe for the treatment of allergies.[2][3][5] DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.[6] It has been shown to be useful in the treatment of Parkinsonism.[7]
Synthesis[edit]
Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine, is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.
Trade names[edit]
Arbid, Dafen, Dayfen, Histyn, Hispril, etc.
References[edit]
- ^ Graham G, Bolt AG (June 1974). "Half-life of diphenylpyraline in man". Journal of Pharmacokinetics and Biopharmaceutics. 2 (3): 191–5. doi:10.1007/BF01059761. PMID 4156058.
- ^ a b Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ^ a b Puhakka H, Rantanen T, Virolainen E (1977). "Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis". J Int Med Res. 5 (1): 37–41. PMID 14039.
- ^ Kubo N, Shirakawa O, Kuno T, Tanaka C (March 1987). "Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay". Japanese Journal of Pharmacology. 43 (3): 277–82. doi:10.1254/jjp.43.277. PMID 2884340.
- ^ Hruby, Victor J.; Ruben Vardanyan; Vardanyan, ۊRuben (2006). Synthesis of essential drugs. Amsterdam: Elsevier. ISBN 0-444-52166-6.
- ^ Lapa G, Mathews T, Harp J, Budygin E, Jones S (2005). "Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties". Eur J Pharmacol. 506 (3): 237–40. doi:10.1016/j.ejphar.2004.11.017. PMID 15627433.
- ^ Ohno T, Kobayashi S, Hayashi M, Sakurai M, Kanazawa I (2001). "Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients". J Neurol Sci. 182 (2): 95–7. doi:10.1016/S0022-510X(00)00441-X. PMID 11137513.
- ^ H.K. Lawrence, R. Kapp, U.S. Patent 2,479,843 (1949).
- ^ W.A. Schuler, DE 934890 (1951).
Aminoalkyl ethers |
|
---|---|
Substituted alkylamines | |
Substituted ethylenediamines |
|
Phenothiazine derivatives | |
Piperazine derivatives | |
Others for systemic use |
|
For topical use |
Dopaminergics |
|
||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Anticholinergics | |||||||||||||||||||
Others | |||||||||||||||||||
|
D1-like |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D2-like |
|
||||||||||||||||||||||||||||||||||||||||||||||||||
Receptor (ligands) |
|
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transporter (inhibitors) |
|
||||||||||||||
Enzyme (inhibitors) |
|
||||||||||||||
Others |
|
![]() |
This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it. |