alpha-Pyrrolidinohexiophenone
From Wikipedia, the free encyclopedia
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oral, intranasal, vaporization, intravenous, rectal, sublingual,subcutaneous |
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| CAS Number | 13415-86-6  HCl: 13415-59-3 |
| PubChem (CID) | 102107923 |
| ChemSpider | 52084419 |
| UNII | 297J9K8A4G |
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| Formula | C16H23NO |
| Molar mass | 245.37 g·mol−1 |
| 3D model (Jmol) | Interactive image |
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α-Pyrrolidinohexiophenone (α-PHP, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s[1] which has been reported as a novel designer drug.[2][3][4][5][6] It is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain, and is a structural isomer of pyrovalerone.[7]
Legality[edit]
The President of the Republic of Italy classified cathinone and all structurally derived analogues (including pyrovalerone analogues) as Narcotics on January 2012. [8][9]
Sweden's public health agency suggested to classify α-PHP as narcotic on June 1, 2015.[10]
As of October 2015 α-PHP is a controlled substance in China.[11]
See also[edit]
- α-PBP
- α-PPP
- α-Pyrrolidinopentiothiophenone (α-PVT)
- 4-Methyl-α-PHP
- Prolintane
- Methylenedioxypyrovalerone
References[edit]
- ^ "US Patent 3314970 - α-Pyrrolidino ketones". Ernst Seeger. Retrieved 18 June 2015.
- ^ Nahoko Uchiyama; Yoshihiko Shimokawa; Maiko Kawamura; Ruri Kikura-Hanajiri; Takashi Hakamatsuka (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products". Forensic Toxicology. 32 (2): 266–281. doi:10.1007/s11419-014-0238-5.
- ^ Milena Majchrzak; Marcin Rojkiewicz; Rafał Celiński; Piotr Kuś; Mieczysław Sajewicz (October 2015). "Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials". Forensic Toxicology. 34: 115–124. doi:10.1007/s11419-015-0295-4. PMC 4705138
. PMID 26793278. - ^ Michael Paul; Sergej Bleicher; Susanne Guber; Josef Ippisch; Aldo Polettini; Wolfgang Schultis (November 2015). "Identification of phase I and II metabolites of the new designer drug α-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)". Journal of Mass Spectrometry. 50 (11): 1305–1317. doi:10.1002/jms.3642. PMID 26505776.
- ^ "α-Pyrrolidinohexanophenone". Cayman Chemical. Retrieved 17 June 2015.
- ^ Janez Klavž; Maksimiljan Gorenjak; Martin Marinšek (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018. PMID 26890319.
- ^ Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry. 49 (4): 1420–1432. doi:10.1021/jm050797a. PMC 2602954. PMID 16480278.
- ^ "Decreto 29 dicembre 2011 (12A00013) (G.U. Serie Generale n. 3 del 4 gennaio 2012)" (PDF).
- ^ "EMCDDA–Europol Joint Report on a new psychoactive substance: 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP)". European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). September 2015.
- ^ "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara". Retrieved 29 June 2015.
- ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
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