Valofane
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| Systematic (IUPAC) name | |
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3-allyl-N-(aminocarbonyl)-5-methyl-2-oxotetrahydrofuran-3-carboxamide
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| Identifiers | |
| CAS Number | 3258-51-3  |
| ATC code | none |
| PubChem | CID 71122 |
| ChemSpider | 64272  |
| UNII | X71N6E5IPO |
| ChEMBL | CHEMBL2104479 |
| Synonyms | N-carbamoyl-5-methyl-2-oxo-3-prop-2-enyloxolane-3-carboxamide |
| Chemical data | |
| Formula | C10H14N2O4 |
| Molar mass | 226.229 g/mol |
| 3D model (Jmol) | Interactive image |
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Valofane is a sedative drug structurally related to the barbiturates[1] and similar drugs such as primidone. It is metabolised once inside the body to form the barbiturate proxibarbital (proxibarbal) and is thus a prodrug.[2]
References[edit]
- ^ Traversa U, Puppini P, Jacquot C, Vertua R. Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice. Journal de Pharmacologie. 1985 Jul-Sep;16(3):279-90.
- ^ Lambrey B, Compagnon PL, Jacquot C. Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats. European Journal of Drug Metabolism and Pharmacokinetics. 1981;6(3):161-9.
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