Thienotriazolodiazepine
From Wikipedia, the free encyclopedia
Not to be confused with thienobenzodiazepine or thienodiazepine.
A thienotriazolodiazepine[1] is a heterocyclic compound containing a diazepine ring fused to a thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:
Thienotriazolodiazepines interact with the benzodiazepine receptor site, they typically have similar effects as 1,4-benzodiazepines (such as diazepam) and triazolobenzodiazepines (such as alprazolam).
Thienotriazolodiazepines that are not GABAA receptor positive allosteric modulators include:
References[edit]
- ^ Catabay, A.; Taniguchi, M.; Jinno, K.; Pesek, J. J.; Williamsen, E. (1 March 1998). "Separation of 1,4-Benzodiazepines and Analogues Using Cholesteryl-10-Undecenoate Bonded Phase in Microcolumn Liquid Chromatography". Journal of Chromatographic Science. 36 (3): 113. doi:10.1093/chromsci/36.3.111.
- ^ Hirota N, Yasuda D, Hashidate T, Yamamoto T, Yamaguchi S, Nagamune T, Nagase T, Shimizu T, Nakamura M. Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. Journal of Biological Chemistry. 2010 Feb 19;285(8):5931-40. doi: 10.1074/jbc.M109.066282. PMID 20007715
![]() |
This article about a heterocyclic compound is a stub. You can help Wikipedia by expanding it. |