Talk:Benzodiazepine

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Good article Benzodiazepine has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do so. If it no longer meets these criteria, you can reassess it.
Article milestones
Date Process Result
February 13, 2009 Good article nominee Not listed
May 19, 2009 Good article nominee Listed
June 24, 2009 Featured article candidate Not promoted
Current status: Good article


medical use of Anterograde amnesia[edit]

Drugs are widely used during medical procedures (colonoscopies etc) that are known to induce short-term Anterograde amnesia; this is not a mere side-effect, but apparently considered at least somewhat desirable, or even the main desired effect, by doctors. It is quite convenient for doctors, for patients to have little memory of what they experienced during medical procedures. Some patients may be grateful for this, some may not -- but they are seldom offered meaningful choices. There are profound and complex ethical aspects to this. The article should address the intentional use of drugs by doctors to induce Anterograde amnesia -- and whether it is indeed always as short-term as intended.-71.174.175.150 (talk) 19:48, 9 December 2014 (UTC)

New material on neurosteroids[edit]

A couple of days ago an IP editor added a paragraph covering the possibility that some of the effects of benzos are mediated by their effects on neurosteroids (diff). I reverted the edit on the basis of inadequate sourcing -- the cited sources are primary research articles. The IP editor reverted the material back into the article, with edit summary "Reverted back to the added text: This text was imported from the article on Neurosteroids and all refererences have been verified. This information is relevant as it may explain the detrimental effects of benzodiazepines on cognition.". Doc James then moved the material to a different point in the article, thereby implicitly validating it.

I continue to feel that the material does not belong as written. Given that benzos have long been known to have direct effects on GABA receptors, we really need some good secondary source to tell us that their indirect effects mediated by neurosteroids are important enough to matter. The first source used in the added material has been cited by a couple of review papers. The most useful, I think, is http://www.sciencedirect.com/science/article/pii/S0091302214000557 (open access), which states, "Similarly, the effects of certain clinically important benzodiazepines (BDZs) may be mediated by (i) binding directly to the GABAAR (at a site between the α and γ subunits) to allosterically and rapidly enhance receptor function and (ii) activating TSPO to produce a delayed indirect enhancement of receptor function by increasing neurosteroid production." (The material that follows adduces evidence for that statement.) In my view this would justify a single sentence in our article saying that in addition to their direct action on GABA receptors, some benzos may also act on them indirectly by increasing production of neurosteroids. Looie496 (talk) 13:44, 1 August 2015 (UTC)

Have trimmed it. Yes better sources needed. Doc James (talk · contribs · email) 14:11, 1 August 2015 (UTC)

External links modified[edit]

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Benzodiazepines & appetite[edit]

All journals articles say Benzodiazepines increases appetite but patients sites say opposite which one is correct? example: http://www.sciencedirect.com/science/article/pii/S0195666380800055

http://www.drugs.com/clonazepam.html — Preceding unsigned comment added by M-G (talk • contribs) 22:45, 18 March 2016 (UTC)

Removed review[edit]

@JzG: What's the diff where the author added his own paper? Anyone else have thoughts on the merit of including this review? Looks like everything is still cited after it is removed. Sizeofint (talk) 00:54, 18 August 2016 (UTC)

Ah, just saw the discussion on your talk page. Found the diff. Sizeofint (talk) 01:29, 18 August 2016 (UTC)

External links modified[edit]

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College of Physicians and Surgeons of British Columbia recommendations[edit]

I am of the opinion that these sorts of specific recommendations from a specific regulatory body in one specific country might be better placed elsewhere as opposed to their current location in the general introductory paragraph of the Medical Uses section. That said, these recommendations are based upon well-established contraindications which are either noticeably absent or given just a scant sentence or two in the current Contraindications section of the article. As such, I recommend that the prescribing recommendations being made by the CPSBC be moved to a new section, perhaps a new subsection under Society and Culture, something along the lines of a 'Recommendations and Best Practices' sort of thing where data such as this from various regional jurisdictions around the globe could be collected. Furthermore, the contraindications on which these recommendations were based should be more clearly detailed in the Contraindications section, perhaps being given full subsection status themselves, alongside the current two which are already there (Pregnancy and Elderly). My understanding of the CPSBC recommendations is that they are primarily motivated by two areas of contraindication, namely taking benzos in concert with other central nervous system depressants such as opioids, barbiturates, alcohol, etc., and prescribing them to patients who have preexisting problems with addiction. Neither of these is very well detailed in the existing article, both are major areas of contraindication with benzodiazepines and both have been exhaustively treated in a veritable wealth of highly credible, peer-reviewed research which is readily available to anyone with an internet connection or a library card. Daystrom (talk) 19:01, 9 December 2016 (UTC)

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