PEPA (drug)
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For the process algebra, see PEPA.
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| Synonyms | PEPA |
| CAS Number | 141286-78-4  |
| PubChem (CID) | 6603828 |
| ChemSpider | 5036138  |
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| Formula | C16H16F2N2O4S2 |
| Molar mass | 402.436 g/mol |
| 3D model (Jmol) | Interactive image |
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PEPA is an ampakine drug which acts as an allosteric potentiator of AMPA receptor desensitisation,[1][2] which is up to 100x more potent than aniracetam in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]
References[edit]
- ^ Sekiguchi, M; Takeo, J; Harada, T; Morimoto, T; Kudo, Y; Yamashita, S; Kohsaka, S; Wada, K (1998). "Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures". British Journal of Pharmacology. 123 (7): 1294–303. doi:10.1038/sj.bjp.0701707. PMC 1565288
. PMID 9579722. - ^ Sekiguchi, M; Nishikawa, K; Aoki, S; Wada, K (2002). "A desensitization-selective potentiator of AMPA-type glutamate receptors". British Journal of Pharmacology. 136 (7): 1033–41. doi:10.1038/sj.bjp.0704804. PMC 1573432. PMID 12145103.
- ^ Sekiguchi, M; Fleck, MW; Mayer, ML; Takeo, J; Chiba, Y; Yamashita, S; Wada, K (1997). "A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide". Journal of Neuroscience. 17 (15): 5760–71. PMID 9221774.
- ^ Sekiguchi, M; Yamada, K; Jin, J; Hachitanda, M; Murata, Y; Namura, S; Kamichi, S; Kimura, I; Wada, K (2001). "The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment". NeuroReport. 12 (13): 2947–50. doi:10.1097/00001756-200109170-00038. PMID 11588608.
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