Cinchocaine
From Wikipedia, the free encyclopedia
(Redirected from Dibucaine)
Clinical data | |
---|---|
AHFS/Drugs.com | International Drug Names |
Routes of administration |
topical, intravenous (for animal euthanasia) |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
|
|
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
ECHA InfoCard | 100.001.484 |
Chemical and physical data | |
Formula | C20H29N3O2 |
Molar mass | 343.463 g/mol |
3D model (Jmol) | |
|
|
|
|
(verify) |
Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Medical use[edit]
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties[edit]
Cinchocaine is relatively insoluble in alkaline aqueous solutions.
See also[edit]
References[edit]
Further reading[edit]
- Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco. 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- Souto-Padron T, Lima AP, de Oliveira Ribeiro R (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res. 99 (4): 317–20. doi:10.1007/s00436-006-0192-1. PMID 16612626.
- Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm. 62 (5): 369–79. PMID 16459486.
- Aroti, A.; Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment .". Journal of Chemical Education. 78 (6): 786–788. doi:10.1021/ed078p786.
This dermatologic drug article is a stub. You can help Wikipedia by expanding it. |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |