Nafadotride

Nafadotride
Names
	IUPAC name N-{[(2S)-1-butylpyrrolidin-2-yl]methyl}-4-cyano-1-methoxy-2-naphthamide
Identifiers
CAS Number	149649-22-9
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL286252
IUPHAR/BPS	44
MeSH	Nafadotride
PubChem	3408722
	SMILES CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC ;
Properties
Chemical formula	C22H27N3O2
Molar mass	365.48 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Nafadotride is a dopamine antagonist with reasonable selectivity for the D₃ subtype (9.6 times selectivity for D₃ over D₂).^[1]

References[edit]

^ Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. Nature. 1999;400:371–375.

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