Tolfenamic acid
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Clinical data | |
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AHFS/Drugs.com | International Drug Names |
Routes of administration |
oral |
ATC code | M01AG02 (WHO) |
Legal status | |
Legal status |
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Identifiers | |
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CAS Number | 13710-19-5 ![]() |
PubChem (CID) | 610479 |
ChemSpider | 530683 ![]() |
UNII | 3G943U18KM ![]() |
KEGG | D01183 ![]() |
ChEBI | CHEBI:32243 ![]() |
ChEMBL | CHEMBL121626 ![]() |
ECHA InfoCard | 100.033.862 |
Chemical and physical data | |
Formula | C14H12ClNO2 |
Molar mass | 261.707 g/mol |
3D model (Jmol) | Interactive image |
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Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland.[2] Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.[3]
It is used in the UK as a treatment for migraine.[4] It is generally not available in the US.[3] It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals.[5]
References[edit]
- ^ Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). = P29890001443 "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities" Check
|url=
value (help). J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443. CS1 maint: Multiple names: authors list (link) - ^ Pentikäinen PJ, et al Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent. Eur J Clin Pharmacol. 1981;19(5):359-65. PMID 7238564
- ^ a b NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
- ^ NHS Tolfenamic Acid (Tolfenamic acid 200mg tablets) Page accessed July 3, 2015
- ^ Drugs.com Drugs.com international listings for tolfenamic acid Page accessed July 3, 2015
External links[edit]
- Tolfenamic acid information (Diseases Database)
Pyrazolones / Pyrazolidines |
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Salicylates | |
Acetic acid derivatives and related substances |
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Oxicams | |
Propionic acid derivatives (profens) |
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N-Arylanthranilic acids (fenamates) |
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Coxibs | |
Other | |
Items listed in bold indicate initially developed compounds of specific groups. #WHO-EM †Withdrawn drugs. ‡Veterinary use medications.
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