GW0742

GW0742
Clinical data
ATC code	None
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid;
CAS Number	317318-84-6
PubChem (CID)	9934458
IUPHAR/BPS	2686
ChemSpider	8110086
KEGG	C15625
ChEMBL	CHEMBL38508
Chemical and physical data
Formula	C21H17F4NO3S2
Molar mass	471.488 g/mol
3D model (Jmol)	Interactive image
	SMILES FC(F)(F)c3c(F)cc(c1nc(c(s1)CSc2cc(c(OCC(=O)O)cc2)C)C)cc3 ;
	InChI InChI=InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28) ; Key:HWVNEWGKWRGSRK-UHFFFAOYSA-N ;

GW0742 (also known as GW610742) is a PPARδ/β agonist^[2]^[3]^[4] that is investigated for drug use by GlaxoSmithKline.^[5]

References[edit]

^ "Cayman Chemical GW0742". Retrieved 31 Mar 2013.
^ Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor β Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.
^ Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research. 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.
^ Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.
^ Wagner, N.; Jehl-Pietri, C.; Lopez, P.; Murdaca, J.; Giordano, C.; Schwartz, C.; Gounon, P.; Hatem, S. N.; Grimaldi, P.; Wagner, K.-D. (2009). "Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin". Cardiovascular Research. 83 (1): 61–71. doi:10.1093/cvr/cvp106. PMID 19351742.

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[1] "Cayman Chemical GW0742". Retrieved 31 Mar 2013.

[2] Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor β Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.

[3] Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research. 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.

[4] Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.

[5] Wagner, N.; Jehl-Pietri, C.; Lopez, P.; Murdaca, J.; Giordano, C.; Schwartz, C.; Gounon, P.; Hatem, S. N.; Grimaldi, P.; Wagner, K.-D. (2009). "Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin". Cardiovascular Research. 83 (1): 61–71. doi:10.1093/cvr/cvp106. PMID 19351742.

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GW0742

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