ELF2

ELF2
Identifiers
Aliases	ELF2, EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2
External IDs	MGI: 1916507 HomoloGene: 5006 GeneCards: ELF2
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • protein binding Cellular component • cytoplasm • nucleoplasm • nucleus Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • cell differentiation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1998	69257
Ensembl	ENSG00000109381	ENSMUSG00000037174
UniProt	Q15723	Q9JHC9
RefSeq (mRNA)	NM_001276457 NM_001276458 NM_001276459 NM_006874 NM_201999 NM_001331036	NM_001291059 NM_001291062 NM_001291063 NM_023502
RefSeq (protein)	NP_001263386 NP_001263387 NP_001263388 NP_001317965 NP_006865 NP_973728	NP_001277988.1 NP_001277991.1 NP_001277992.1 NP_075991.1
Location (UCSC)	Chr 4: 139.03 – 139.18 Mb	Chr 3: 51.25 – 51.34 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. In humans this protein is encoded by the ELF2 gene.

Further reading

• Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.". Leukemia. 11 (1): 86–96. doi:10.1038/sj.leu.2400516. PMID 9001422. 
• Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.". Mol. Cell. Biol. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087. 
• Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia.". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb.10148. PMID 11967990. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression.". Biochem. Biophys. Res. Commun. 356 (3): 536–41. doi:10.1016/j.bbrc.2007.02.160. PMID 17368566.