ICI-85966

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ICI-85966
ICI-85966.svg
Identifiers
Systematic (IUPAC) name: [4-[(E)-4-[4-[Bis(2-chloroethyl)carbamoyloxy]phenyl]hex-3-en-3-yl]phenyl] N,N-bis(2-chloroethyl)carbamate
Synonyms Stilbostat
CAS Number 15470-58-3
PubChem (CID) 3037081
ChemSpider 2300916
Chemical and physical data
Formula C28H34Cl4N2O4
Molar mass 604.39256 g/mol
3D model (Jmol) Interactive image

ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol bis(di(2-chloroethyl)carbamate), is a synthetic, non-steroidal estrogen and alkylating antineoplastic agent of the stilbestrol group and a cytostatic nitrogen mustard ester of diethylstilbestrol (DES) that was developed for the treatment of breast cancer and prostate cancer but was never marketed.[1][2][3][4][5] It was found to markedly improve the clinical state in approximately 65% of women treated with it for advanced breast cancer in a clinical study.[4]

See also[edit]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 397. ISBN 978-1-4757-2085-3. 
  2. ^ Zimel H, Broder D, Zimel A (1973). "[Therapeutic effects of the preparation "Stilbostat" in advanced stages of breast cancer after the menopause]". Stud Cercet Endocrinol (in Romanian). 24 (3): 211–9. PMID 4703920. 
  3. ^ Görlich M, Heise E (1976). "Contribution to the mechanism of Stilbostat action". Neoplasma. 23 (4): 363–9. PMID 1004653. 
  4. ^ a b Zimel H, Mogos I, Maltezeanu G (1977). "Estimation of StilbostatR treatment efficiency in breast cancer by thermography". Neoplasma. 24 (5): 553–7. PMID 927612. 
  5. ^ Zimel H, Bocancea D (1974). "Treatment of prostatic carcinoma with Stilbostat". Neoplasma. 21 (1): 101–8. PMID 4596007. 


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