A man has been shot in the chest and killed in what is believed to be a targeted attack in Sydney's west overnight.
Homicide squad detectives have launched an investigation into the 37-year-old man's death at the house on Kennedy Street in Guildford on Wednesday night.
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Fatal shooting in Guildford
A manhunt is under way after a 37-year-old man man was shot dead at a house in Sydney's west. Vision courtesy Seven Network.
Police received a triple-zero call about 11.10pm to say that a man had been shot and was seriously injured.
NSW Ambulance paramedics arrived a short time later to find a man in cardiac arrest with a gunshot wound to his chest. They attempted to revive him, but he died at the scene.
Forensic police, along with detectives from the Homicide Squad and the Rosehill Local Area Command, remained at the house early on Thursday morning examining the crime scene.
No arrests have been made over the man's death, and police are understood to be investigating whether up to three people were involved in the shooting.
Police could not immediately say whether the man was inside the house when he was shot.
Police have urged anyone who was on Kennedy Street about 11pm on Wednesday, or who saw any suspicious activity in the area, to contact Crime Stoppers on 1800 333 000.