Fluproquazone
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Clinical data | |
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ATC code | none |
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CAS Number | 40507-23-1 |
PubChem (CID) | 38503 |
ChemSpider | 35289 |
UNII | U4K85O58HD |
KEGG | D04229 |
Chemical and physical data | |
Formula | C18H17FN2O |
Molar mass | 296.339 g/mol |
3D model (Jmol) | Interactive image |
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Fluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz.[1][2][3][4] It was withdrawn during development due to liver toxicity.[5]:370[6]:520
References[edit]
- ^ Haanaes HR, et al RF 46-790 versus paracetamol: effect on post-operative pain. Int J Clin Pharmacol Ther Toxicol. 1986 Nov;24(11):598-601. PMID 3491794
- ^ Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20.
- ^ Wheatley D. Analgesic properties of fluproquazone. Rheumatology and Rehabilitation. 1982 May;21(2):98-100.
- ^ Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5.
- ^ Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists, Ch 22 in Drug-induced Liver Disease (Third Edition). Eds Neil Kaplowitz and Laurie D. DeLeve. Elsevier Inc, 2013. ISBN 9780123878175
- ^ Hyman J. Zimmerman. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. Lippincott Williams & Wilkins, 1999. ISBN 9780781719520
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