WAY-213,613
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| CAS Number | 868359-05-1  |
| PubChem (CID) | 11531745 |
| IUPHAR/BPS | 4531 |
| ChemSpider | 9706528  |
| ChEMBL | CHEMBL1628669 |
| ECHA InfoCard | 100.212.988 |
| Chemical and physical data | |
| Formula | C16H13BrF2N2O4 |
| Molar mass | 415.186 g/mol |
| 3D model (Jmol) | Interactive image |
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WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT2, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.[1] It is used in scientific research into the function of the glutamate transporters.[2]
References[edit]
- ^ Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A; et al. (2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology. 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807.
- ^ Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience. 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521.
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