Piretanide
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| Clinical data | |
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| Trade names | Arelix, Eurelix, Tauliz |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration |
Oral |
| ATC code | C03CA03 (WHO) |
| Legal status | |
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| Pharmacokinetic data | |
| Bioavailability | ~90%[1] |
| Protein binding | 96% |
| Metabolism | not identified |
| Excretion | Urine (60%), feces (40%) |
| Identifiers | |
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| CAS Number | 55837-27-9  |
| PubChem (CID) | 4849 |
| IUPHAR/BPS | 4742 |
| DrugBank | DB02925  |
| ChemSpider | 4683 |
| UNII | DQ6KK6GV93 |
| KEGG | D01634 |
| ECHA InfoCard | 100.054.394 |
| Chemical and physical data | |
| Formula | C17H18N2O5S |
| Molar mass | 362.40 g/mol |
| 3D model (Jmol) | Interactive image |
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Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic[2] compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups. Studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics such as furosemide and bumetanide found a more suitable dose/response rate (regression line) and a more favourable sodium/potassium excretion ratio. These findings led eventually to clinical studies in man and finally to the introduction as a saluretic and antihypertensive[3] medication in Germany, France, Italy and other countries.
References[edit]
- ^ Mutschler, Edited by Rainer F. Greger, H. Knauf, E. Mutschler (1995). Diuretics. Handbook of Experimental Pharmacology (Том 117). Berlin, Heidelberg: Springer Science & Business Media, 2012. p. 517. ISBN 364279565X.
- ^ Musini, V. M.; Wright, J. M.; Bassett, K.; Jauca, C. D. (2009). Musini, Vijaya M, ed. "Blood pressure lowering efficacy of loop diuretics for primary hypertension". The Cochrane Library (4): CD003825. doi:10.1002/14651858.CD003825.pub2. PMID 19821314.
- ^ Haberfeld, H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 3-85200-196-X.
- W.Merkel, D.Bormann, D.Mania, R.Muschaweck and M.Hropot, Eur. J. Med. Chem.-Chim.Ther. 11,399 (1976).
- W.Merkel, D.Mania and D.Bormann, Liebigs Ann. Chem. 461 (1979).
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