SDZ SER-082
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| Formula | C15H20N2 |
| Molar mass | 228.332 g/mol |
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SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2][3][4] and how they influence the effects of other drugs such as cocaine.[5][6][7]
References[edit]
- ^ Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. doi:10.1021/jm00001a007
- ^ Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology, Biochemistry, and Behavior. 58 (4): 1051–7. doi:10.1016/S0091-3057(97)00057-9. PMID 9408213.
- ^ Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology, Biochemistry, and Behavior. 72 (1-2): 371–8. doi:10.1016/S0091-3057(01)00767-5. PMID 11900808.
- ^ Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology, Biochemistry, and Behavior. 90 (4): 632–9. doi:10.1016/j.pbb.2008.05.006. PMID 18572227.
- ^ Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246–54. doi:10.1124/jpet.104.068841. PMID 15131246.
- ^ Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports : PR. 57 (1): 35–46. PMID 15849375.
- ^ Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology. 183 (4): 482–9. doi:10.1007/s00213-005-0197-y. PMID 16261316.
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