Monoamine oxidase A

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MAOA
Monoamine oxidase A 2BXS.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAOA, MAO-A, monoamine oxidase A
External IDs OMIM: 309850 MGI: 96915 HomoloGene: 203 GeneCards: MAOA
Targeted by Drug
befloxatone, clorgiline, moclobemide, pirlindole, tranylcypromine, phenelzine[1]
RNA expression pattern
PBB GE MAOA 204388 s at tn.png

PBB GE MAOA 204389 at tn.png

PBB GE MAOA 212741 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez

4128

17161
Ensembl

ENSG00000189221

ENSMUSG00000025037
UniProt

P21397

Q64133
RefSeq (mRNA)

NM_001270458
NM_000240

NM_173740
RefSeq (protein)

NP_000231
NP_001257387

NP_776101.3
Location (UCSC) Chr X: 43.65 – 43.75 Mb Chr X: 16.62 – 16.69 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse
MAOA gene is located on the short (p) arm of the X chromosome at position 11.3.

Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the MAOA gene.[4][5] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. A mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.[6]

Structure[edit]

Gene[edit]

The promoter of MAOA contains conserved binding sites for Sp1, GATA2, and TBP.[7] This gene is adjacent to a related gene (MAOB) on the opposite strand of the X chromosome.

Protein[edit]

This gene encodes a monomeric protein which shares a 70% amino acid sequence identity, as well as conserved chain folds and flavin adenine dinucleotide (FAD)-binding site structures, with MAO-B. However, MAO-A has a monopartite cavity of approximately 550 angstroms, compared to the 290-angstrom bipartite cavity in MAO-B. Nonetheless, both proteins adopt dimeric forms when membrane-bound. The C-terminal domain of MAO-A forms helical tails which are responsible for attaching the protein to the outer mitochondrial membrane (OMM). MAO-A contains loop structures at the entrance of its active site.[8]

Function[edit]

MAO-A is a flavoenzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin, via oxidative deamination. As a result, it is a key regulator for normal brain function. The protein is highly expressed in neural and cardiac cells and localizes to the outer mitochondrial membrane. Its expression is regulated by the transcription factors SP1, GATA2, and TBP via the CAMP pathway in response to stress such as ischemia and inflammation.[7]

Clinical significance[edit]

Cancer[edit]

MAO-A produces an amine oxidase, which is a class of enzyme known to affect carcinogenesis. Clorgyline, an MAO-A enzyme inhibitor, prevents apoptosis in melanoma cells, in vitro.[9] Cholangiocarcinoma suppresses MAO-A expression, and those patients with higher MAO-A expression had less adjacent organ invasion and better prognosis and survival.[10]

Cardiovascular disease[edit]

MAOA activity is linked to apoptosis and cardiac damage during cardiac injury following ischemic-reperfusion.[7]

Behavioral and neurological disorders[edit]

There is a link between low activities forms of the MAOA gene and autism.[11] Mutations in the MAOA gene results in monoamine oxidase deficiency, or Brunner syndrome.[6] Other disorders associated with MAO-A include Alzheimer's disease, aggression, panic disorder, bipolar affective disorder, major depressive disorder, and attention deficit hyperactivity disorder.[7] Effects of parenting on self-regulation in adolescents appear to be moderated by 'plasticity alleles', of which the 2R and 3R alleles of MAOA are two, with "the more plasticity alleles males (but not females) carried, the more and less self-regulation they manifested under, respectively, supportive and unsupportive parenting conditions." [12]

Depression[edit]

MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder.[13] Genetic association studies examining the relationship between high-activity MAOA variants and depression have produced mixed results, with some studies linking the high-activity variants to major depression in females,[14] depressed suicide in males,[15] major depression and sleep disturbance in males[16] and major depressive disorder in both males and females.[17]

Other studies failed to find a significant relationship between high-activity variants of the MAOA gene and major depressive disorder.[18][19] In patients with major depressive disorder, those with MAOA G/T polymorphisms (rs6323) coding for the highest-activity form of the enzyme have a significantly lower magnitude of placebo response than those with other genotypes.[20]

Antisocial behavior[edit]

In humans, there is a 30-base repeat sequence repeated in one of several different numbers of times in the promoter region of the gene coding for MAO-A. There are 2R (two repeats), 3R, 3.5R, 4R, and 5R variants of the repeat sequence, with the 3R and 4R variants most common in Caucasians. The 3.5R and 4R variants have been found to be more highly active than 3R or 5R, in a study which did not examine the 2R variant.[21] An association between the 2R allele of the VNTR region of the gene and an increase in the likelihood of committing serious crime or violence has been found.[21][22][23]

A connection between a version of the monoamine oxidase A gene (3R) and several types of antisocial behavior has been found. Maltreated children with genes causing high levels of MAO-A were less likely to develop antisocial behavior.[24] Low MAO-A activity in combination with abuse experienced during childhood results in an increased risk of aggressive behaviour as an adult,[25] and there is evidence suggesting that men with the low activity MAOA allele are more genetically vulnerable even to punitive discipline as a predictor of antisocial behaviour.[26] High testosterone, maternal tobacco smoking during pregnancy, poor material living standards, dropping out of school, and low IQ also predicts violent behavior in men with the low-activity alleles (which are overwhelmingly the 3R allele).[27][28] Even in the absence of such interaction factors, the 3R allele has a small main effect on aggression and antisocial behavior, according to a large meta-analysis, which found no significant publication bias.[29]

Aggression and the "Warrior gene"[edit]

A version of the monoamine oxidase-A gene has been popularly referred to as the warrior gene.[30] Several different versions of the gene are found in different individuals, although a functional gene is present in most humans (with the exception of a few individuals with Brunner syndrome).[31] In the variant, the allele associated with behavioural traits is shorter (30 bases) and may produce less MAO-A enzyme.[32] This gene variation is in a regulatory promoter region about 1000 bases from the start of the region that encodes the MAO-A enzyme.

Studies have found differences in the frequency distribution of variants of the MAOA gene between ethnic groups:[32][33] of the participants, 59% of Black men, 54% of Chinese men, 56% of Maori men, and 34% of Caucasian men carried the 3R allele, while 5.5% of Black men, 0.1% of Caucasian men, and 0.00067% of Asian men carried the 2R allele.[23][32][33][34][35][36][37][38][39][40]

When faced with social exclusion or ostracism, individuals with the low activity MAOA gene showed higher levels of aggression than individuals with the high activity MAOA gene.[41] Low activity MAO-A could significantly predict aggressive behaviour in a high provocation situation, but was less associated with aggression in a low provocation situation. Individuals with the low activity variant of the MAOA gene were just as likely as participants with the high activity variant to retaliate when the loss was small. However, they were more likely to retaliate and with greater force when the loss was large.[42]

“Monoamine oxidases (MAOs) are enzymes that are involved in the breakdown of neurotransmitters such as serotonin and dopamine and are, therefore, capable of influencing feelings, mood, and behaviour of individuals”.[43] According to this, if there was a mutation to the gene that is involved in the process of promoting or inhibiting MAO enzymes, it could affect a person’s personality or behaviour and could therefore make them more prone to aggression. A deficiency in the MAOA gene has shown higher levels of aggression in males, which could further stimulate more research into this controversial topic. “A deficiency in monoamine oxidase A (MAO-A) has been shown to be associated with aggressive behaviour in men of a Dutch family”.[44]

Legal implications[edit]

In a 2009 criminal trial in the United States, an argument based on a combination of "warrior gene" and history of child abuse was successfully used to avoid a conviction of first-degree murder and the death penalty; however, the convicted murderer was sentenced to 32 years in prison.[45][46] The results showed the effects of the 4-repeat allele of MAOA promoter polymorphism on physical aggressive behavior for women. It seems that there is an interaction between the 3-repeat allele of MAOA promoter polymorphism and emotional abuse experiences on aggressive behavior for women.[45]

Epigenetics[edit]

Epigenetics likely plays an important role in the expression of the MAOA gene through methylation in women.[47] Studies have linked methylation of the MAOA gene with nicotine and alcohol dependence in women.[48] A second MAOA VNTR promoter, P2, influences epigenetic methylation and interacts with having experienced child abuse to influence antisocial personality disorder symptoms, only in women.[49] Another study found epigenetic methylation of MAOA in men to be very low and with little variability compared to women, while having higher heritability in men than women.[50]

Animal studies[edit]

A dysfunctional MAOA gene has been correlated with increased aggression levels in mice,[51][52] and has been correlated with heightened levels of aggression in humans.[53] In mice, a dysfunctional MAOA gene is created through insertional mutagenesis (called ‘Tg8’).[51] Tg8 is a transgenic mouse strain that lacks functional MAO-A enzymatic activity. Mice that lacked a functional MAOA gene exhibited increased aggression towards intruder mice.[51][54]

Some types of aggression exhibited by these mice were territorial aggression, predatory aggression, and isolation-induced aggression.[52] The MAO-A deficient mice that exhibited increased isolation-induced aggression reveals that an MAO-A deficiency may also contribute to a disruption in social interactions.[55] There is research in both humans and mice to support that a nonsense point mutation in the eighth exon of the MAOA gene is responsible for impulsive aggressiveness due to a complete MAO-A deficiency.[51][53]

Interactions[edit]

Transcription factors[edit]

A number of transcription factors that the bind to the promoter of MAO-A and thereby up regulate its expression. These include:

Inducers[edit]

Synthetic compounds that up regulate the expression of MAO-A include:

Inhibitors[edit]

Main articles: Reversible inhibitor of monoamine oxidase A and Monoamine oxidase inhibitor

Substances that inhibit the enzymatic activity of MAO-A include:

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Monoamine oxidase A view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
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  5. ^ Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC (May 1991). "Human monoamine oxidase A and B genes exhibit identical exon-intron organization". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3637–41. doi:10.1073/pnas.88.9.3637. PMC 51507Freely accessible. PMID 2023912. 
  6. ^ a b "Entrez Gene: MAOA monoamine oxidase A". 
  7. ^ a b c d e Gupta V, Khan AA, Sasi BK, Mahapatra NR (Jul 2015). "Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia-like conditions: key roles of the transcription factors GATA2, Sp1 and TBP". Journal of Neurochemistry. 134 (1): 21–38. doi:10.1111/jnc.13099. PMID 25810277. 
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Rehan W., Sandnabba N.K., Johansson A., Westberg L., & Santtila P. (2015). Effects of MAOA genotype and childhood experiences of physical and emotional abuse on aggressive behavior in adulthood. Nordic Psychology. DOI:10.1080/19012276.2015.1026922.

Further reading[edit]

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