Ro60-0175

Ro60-0175
Identifiers
	IUPAC name (S)-6-Chloro-5-fluoro-1H-indole-2-propanamine;
PubChem CID	3045227;
IUPHAR/BPS	274;
ChemSpider	2308002;
ECHA InfoCard	100.189.524
Chemical and physical data
Formula	C11H12ClFN2
Molar mass	226.677 g/mol
3D model (Jmol)	Interactive image;
	SMILES C[C@@H](Cn1ccc2c1cc(c(c2)F)Cl)N ;
	InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1 ; Key:XJJZQXUGLLXTHO-ZETCQYMHSA-N ;
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Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.^[1]^[2] It acts as a potent and selective agonist for both the 5-HT_2B and 5-HT_2C serotonin receptor subtypes, with good selectivity over the closely related 5-HT_2A subtype, and little or no affinity at other receptors.^[3]^[4]

References[edit]

^ Quarta D, Naylor CG, Stolerman IP. The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Psychopharmacology (Berlin). 2007 Aug;193(3):391-402. PMID 17473916
^ Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008 May;33(6):1402-12. PMID 17653111
^ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British Journal of Pharmacology. 1999 Sep;128(1):13-20. doi:10.1038/sj.bjp.0702751 PMID 10498829
^ Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, Kindel GH, Haskins KA, Shankaran M, Petersen BR, Van De Kar LD. Neuroendocrine evidence that (S)-2-(6-chloro-5-fluoro-indol-1-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist. Journal of Pharmacology and Experimental Therapeutics. 2003 Mar;304(3):1209-16. PMID 12604698

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[1] Quarta D, Naylor CG, Stolerman IP. The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Psychopharmacology (Berlin). 2007 Aug;193(3):391-402. PMID 17473916

[2] Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008 May;33(6):1402-12. PMID 17653111

[3] Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British Journal of Pharmacology. 1999 Sep;128(1):13-20. doi:10.1038/sj.bjp.0702751 PMID 10498829

[4] Damjanoska KJ, Muma NA, Zhang Y, D'Souza DN, Garcia F, Carrasco GA, Kindel GH, Haskins KA, Shankaran M, Petersen BR, Van De Kar LD. Neuroendocrine evidence that (S)-2-(6-chloro-5-fluoro-indol-1-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine(2C) receptor agonist. Journal of Pharmacology and Experimental Therapeutics. 2003 Mar;304(3):1209-16. PMID 12604698

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Ro60-0175

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Identifiers

IUPAC name (S)-6-Chloro-5-fluoro-1H-indole-2-propanamine
PubChem CID	3045227
IUPHAR/BPS	274
ChemSpider	2308002
ECHA InfoCard	100.189.524
Chemical and physical data
Formula	C₁₁H₁₂ClFN₂
Molar mass	226.677 g/mol
3D model (Jmol)	Interactive image
SMILES C[C@@H](Cn1ccc2c1cc(c(c2)F)Cl)N
InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1 Key:XJJZQXUGLLXTHO-ZETCQYMHSA-N
(verify)