Glabrene
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Names | |
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IUPAC name
8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol
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Other names
2',2'-dimethyl-2H,2'H-3,8'-bichromene-5',7-diol
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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Properties | |
C20H18O4 | |
Molar mass | 322.36 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Glabrene is an isoflavonoid that is found in Glycyrrhiza glabra (licorice).[1] It has estrogenic activity, showing estrogenic effects on breast, vascular, and bone tissue, and hence is a phytoestrogen (IC50 for estrogen receptor binding = 1 μM).[1][2][3] It has also been found to act as a tyrosinase inhibitor (IC50 = 3.5 μM) and to inhibit the formation of melanin in melanocytes, and for these reasons, has been suggested as a potential skin-lightening agent.[4]
See also[edit]
References[edit]
- ^ a b Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J (2001). "Estrogen-like activity of glabrene and other constituents isolated from licorice root". J. Steroid Biochem. Mol. Biol. 78 (3): 291–8. PMID 11595510.
- ^ Somjen D, Knoll E, Vaya J, Stern N, Tamir S (2004). "Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo". J. Steroid Biochem. Mol. Biol. 91 (3): 147–55. PMID 15276622. doi:10.1016/j.jsbmb.2004.04.003.
- ^ Somjen D, Katzburg S, Vaya J, Kaye AM, Hendel D, Posner GH, Tamir S (2004). "Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues". J. Steroid Biochem. Mol. Biol. 91 (4-5): 241–6. PMID 15336701. doi:10.1016/j.jsbmb.2004.04.008.
- ^ Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S (2003). "Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots". J. Agric. Food Chem. 51 (5): 1201–7. PMID 12590456. doi:10.1021/jf020935u.
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