DR-4485

DR-4485
Identifiers
	IUPAC name 6-chloro-2a-(4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl)-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)one;
CAS Number	402942-53-4
PubChem (CID)	9911844
Chemical and physical data
Formula	C26H28Cl2N2O
Molar mass	455.418 g/mol
3D model (Jmol)	Interactive image
	SMILES c4cc(Cl)ccc4C(CC5)=CCN5CCCCC2(CCC3)c1c3c(Cl)ccc1NC2=O ;

DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT₇ receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.^[1]^[2]

References[edit]

^ Kikuchi C, Suzuki H, Hiranuma T, Koyama M. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorganic and Medicinal Chemistry Letters. 2003 Jan 6;13(1):61-4. PMID 12467617
^ Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2384-92. DOI 10.1021/jm8014553. PMID 19326916

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[1] Kikuchi C, Suzuki H, Hiranuma T, Koyama M. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorganic and Medicinal Chemistry Letters. 2003 Jan 6;13(1):61-4. PMID 12467617

[2] Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2384-92. DOI 10.1021/jm8014553. PMID 19326916

[1]

[2]

DR-4485

References[edit]

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Identifiers

IUPAC name 6-chloro-2a-(4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl)-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)one
CAS Number	402942-53-4^N
PubChem (CID)	9911844
Chemical and physical data
Formula	C₂₆H₂₈Cl₂N₂O
Molar mass	455.418 g/mol
3D model (Jmol)	Interactive image
SMILES c4cc(Cl)ccc4C(CC5)=CCN5CCCCC2(CCC3)c1c3c(Cl)ccc1NC2=O