Meclofenoxate
Clinical data | |
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AHFS/Drugs.com | International Drug Names |
ATC code | N06BX01 (WHO) |
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CAS Number | 51-68-3 |
PubChem (CID) | 4039 |
ChemSpider | 3899 |
UNII | C76QQ2I0RG |
KEGG | D00993 |
ECHA InfoCard | 100.000.107 |
Chemical and physical data | |
Formula | C12H16ClNO3 |
Molar mass | 257.713 |
3D model (Jmol) | Interactive image |
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Meclofenoxate (INN, BAN) (brand name Lucidril), also known as centrophenoxine, is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease.[1][2][3] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish, while pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.
In elderly patients, meclofenoxate has been found clinically to improve memory, have a mentally stimulating effect, and improve general cognition.[4] Meclofenoxate also increases cellular membrane phospholipids.[citation needed] Although meclofenoxate is generally considered to be a dietary supplement, in some European countries, such as Germany, Hungary, and Austria, as well as Japan, it is a prescription drug.[3]
Side effects[edit]
Meclofenoxate is considered to be very safe and high in tolerability.[3] However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.[3]
Research[edit]
Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 30–50%, and thus may be anti-aging drugs/supplements.[5]
Brand names[edit]
In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[6]
See also[edit]
References[edit]
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1.
- ^ a b c d Maija Haavisto (1 May 2008). Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia. Lulu.com. pp. 167–. ISBN 978-1-4092-0335-3.
- ^ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing. 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
- ^ The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. 1 January 2003. pp. 66–. ISBN 978-0-9668937-3-1.
- ^ Yong Zhou (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN 978-1-4831-9193-5.
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