2β-Propanoyl-3β-(2-naphthyl)-tropane
From Wikipedia, the free encyclopedia
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| Pharmacokinetic data | |
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| Bioavailability | high |
| Metabolism | slow |
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| PubChem (CID) | 10447943 |
| ChemSpider | 8623360 |
| Chemical and physical data | |
| Formula | C21H25NO |
| Molar mass | 307.43 g/mol |
| 3D model (Jmol) | Interactive image |
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2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 is a cocaine analogue. It is claimed to be several hundred times more potent than cocaine at being serotonin-norepinephrine-dopamine reuptake inhibitor.[1]
As can be seen on pubmed, these acyl substituted phenyltropanes are highly potent MAT inhibitors and also have a very long half-life, spanning perhaps at least a few days.[2] [3]
See also[edit]
External links[edit]
- (Satendra Singh, 2000) Page 16-17
References[edit]
- ^ U.S. Patent 6,008,227
- ^ Bennett, B. A.; Wichems, C. H.; Hollingsworth, C. K.; Davies, H. M.; Thornley, C.; Sexton, T.; Childers, S. R. (1 March 1995). "Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain.". Journal of Pharmacology and Experimental Therapeutics. 272 (3): 1176–1186. PMID 7891330.
- ^ Daunais, J. B.; Hart, S. L.; Smith, H. R.; Letchworth, S. R.; Davies, H. M. L.; Sexton, T.; Bennett, B. A.; Childers, S. R.; Porrino, L. J. (1 June 1998). "Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2β-Propanoyl-3β-(2-Naphthyl)-Tropane". Journal of Pharmacology and Experimental Therapeutics. 285 (3): 1246–1254. PMID 9618429.
