AB-005

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AB-005
AB-005.png
Legal status
Legal status
Identifiers
Systematic (IUPAC) name: [1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
CAS Number 895155-25-6
PubChem (CID) 11537652
ChemSpider 9712433
ChEMBL CHEMBL571330
Chemical and physical data
Formula C23H32N2O
Molar mass 352.51 g/mol
3D model (Jmol) Interactive image

AB-005 or [1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone is a designer drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (Ki = 5.5 nM) and CB2 receptors (Ki = 0.48 nM).[1] AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group of UR-144 and XLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent of AM-1248 and AM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans.

Legal status[edit]

Psychoactive products in New Zealand containing this drug have been given interim approval under recent psychoactive substances legislation.[2]

See also[edit]

References[edit]

  1. ^ Frost, J. M.; et al. (2010). "Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity". Journal of Medicinal Chemistry. 53 (1): 295–315. doi:10.1021/jm901214q. PMID 19921781. 
  2. ^ Ministry of Health – Manatū Hauora "Interim Product Approvals", Ministry of Health NZ, New Zealand, 2 January 2013. Retrieved on 2 January 2013.