ACPD
From Wikipedia, the free encyclopedia
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Names | |
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Systematic IUPAC name
1-Aminocyclopentane-1,3-dicarboxylic acid[1]
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Identifiers | |
39026-63-6 ![]() 56827-69-1 (1R,3S) ![]() 111900-32-4 (1S,3R) ![]() |
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3D model (Jmol) | Interactive image |
Abbreviations | ACPD |
ChEMBL | ChEMBL168278 ![]() |
ChemSpider | 1270 ![]() 201559 (1R,3R) ![]() 66220 (1R,3S) ![]() 94574 (1S,3R) ![]() 5036967 (1S,3S) ![]() |
MeSH | 1-amino-1,3-dicarboxycyclopentane |
PubChem | 1310 44381972 (1S) 231345 (1R,3R) 73537 (1R,3S) 104766 (1S,3R) 6604704 (1S,3S) |
RTECS number | GY4060000 (1S,3R) |
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Properties | |
C7H11NO4 | |
Molar mass | 173.17 g·mol−1 |
Appearance | White crystals |
20 g dm−3 | |
Solubility in ethanol | 240 mg dm−3 |
log P | -0.709 |
Acidity (pKa) | 2.112 |
Basicity (pKb) | 11.885 |
Isoelectric point | 2.84 |
Hazards | |
GHS pictograms | ![]() |
GHS signal word | Warning |
H302, H312, H315, H319, H332, H335 | |
P261, P280, P305+351+338 | |
EU classification (DSD)
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R-phrases | R20/21/22, R36/37/38 |
S-phrases | S26, S36/37 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
1-Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that binds to the metabotropic glutamate receptor (mGluR),[2] acting as a mGluR agonist. ACPD is a rigid analogue of the neurotransmitter glutamate and does not activate ionotropic glutamate receptors.[3] ACPD can induce convulsions in neonatal rats.[4]
References[edit]
- ^ "1-amino-1,3-dicarboxycyclopentane - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. Retrieved 15 October 2011.
- ^ Schoepp DD, True RA (September 1992). "1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes". Neurosci. Lett. 145 (1): 100–4. doi:10.1016/0304-3940(92)90213-Q. PMID 1461560.
- ^ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (July 1990). "(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes". Mol. Pharmacol. 38 (1): 1–6. PMID 2164627.
- ^ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (October 1993). "Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist". J. Neurosci. 13 (10): 4445–55. PMID 8410197.
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