Protopine
From Wikipedia, the free encyclopedia
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| Names | |
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| IUPAC name
7-Methyl-6,8,9,16-tetrahydrobis[1,3]benzodioxolo[4,5-c:5′,6′-g]azecin-15(7H)-one
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| Identifiers | |
130-86-9  |
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| 3D model (Jmol) | Interactive image |
| ChEBI | CHEBI:16415  |
| ChEMBL | ChEMBL486179 |
| ChemSpider | 4799 |
| ECHA InfoCard | 100.004.546 |
| EC Number | 204-999-6 |
| KEGG | C05189 |
| PubChem | 4970 |
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| Properties | |
| C20H19NO5 | |
| Molar mass | 353.369 g/mol |
| Appearance | white crystals |
| Density | 1.399 g/cm3 |
| Melting point | 208 °C (406 °F; 481 K) |
| practically insoluble | |
| Solubility in chloroform | 1:15 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 verify (what is ?) |
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| Infobox references | |
Protopine is a benzylisoquinoline alkaloid occurring in opium poppy,[2] Corydalis tubers[3] and other plants of the family papaveraceae, like Fumaria officinalis.[4] It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.[5][6]
See also[edit]
References[edit]
- ^ The Merck Index (9 ed.). New Jersey: Merck & Co. 1976. p. 1023.
- ^ The Free Dictionary: Protopine
- ^ Jiang, B; Cao, K; Wang, R (2004). "Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.". European Journal of Pharmacology. 506 (2): 93–100. doi:10.1016/j.ejphar.2004.11.004. PMID 15588728.
- ^ Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). "Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR". Toxicology Letters. 203 (2): 135–141. doi:10.1016/j.toxlet.2011.03.015. PMID 21419197.
- ^ Saeed, SA; Gilani, AH; Majoo, RU; Shah, BH (1997). "Anti-thrombotic and anti-inflammatory activities of protopine.". Pharmacological research : the official journal of the Italian Pharmacological Society. 36 (1): 1–7. doi:10.1006/phrs.1997.0195. PMID 9368908.
- ^ Protopine at the US National Library of Medicine Medical Subject Headings (MeSH)
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