Bromazine

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Not to be confused with Promazine.
Bromazine
Bromazine.svg
Clinical data
MedlinePlus a682065
Routes of
administration
Oral
ATC code R06AA01 (WHO)
Pharmacokinetic data
Bioavailability High
Protein binding 96%
Metabolism Mostly hepatic (CYP-mediated), also renal
Biological half-life 1 to 4 hours
Identifiers
CAS Number 1808-12-4 YesY 1808-12-4
PubChem (CID) 2444
IUPHAR/BPS 7132
DrugBank DB01237 YesY
ChemSpider 2350 YesY
UNII 202J683U97 YesY
ChEBI CHEBI:59177 YesY
ChEMBL CHEMBL1201245 N
ECHA InfoCard 100.003.854
Chemical and physical data
Formula C17H20BrNO
Molar mass 334.251 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Bromazine (trade names Ambrodyl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic.[1] It is a halogenated form of diphenhydramine and in many respects is somewhat stronger than the parent compound. The other three halogenated diphenhydramine derivatives are used in research and chlorodiphenhydramine is also marketed with iododiphenhydramine being a much less common pharmaceutical.

References[edit]

  1. ^ MacLaren, W. R.; Bruff, W. C.; Eisenberg, B. C.; Weiner, H.; Martin, W. H. (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of allergy. 13 (3): 307–312. PMID 14377226.