Irazepine
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| Systematic (IUPAC) name | |
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7-chloro-5-(2-fluorophenyl)-1-(2-isothiocyanatoethyl)-3H-1,4-benzodiazepin-2-one
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| Identifiers | |
| CAS Number | 71735-92-7  |
| PubChem | CID 194406 |
| ChemSpider | 168688 |
| Chemical data | |
| Formula | C18H13ClFN3OS |
| Molar mass | 373.83 g/mol |
| 3D model (Jmol) | Interactive image |
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Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group.[1] It is a non-competitive benzodiazepine binding site antagonist.[2] Irazepine and other alkylating benzodiazepine, kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.[3]
References[edit]
- ^ Edited by Ganellin, CR; Triggle, DJ (1999). Dictionary of Pharmacological Agents. (1st ed.). London: Chapman & Hall. ISBN 9780412466304.
- ^ Hall, Ian K.M. Morton, Judith M. (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. p. 156. ISBN 978-94-011-4439-1.
- ^ Williams, EF; Rice, KC; Mattson, M; Paul, SM; Skolnick, P (April 1981). "In Vivo Effects of Two Novel Alkylating Benzodiazepines, Irazepine and Kenazepine". Pharmacology, Biochemistry, and Behavior. 14 (4): 487–91. doi:10.1016/0091-3057(81)90307-5. PMID 7232472.
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