Gliquidone
From Wikipedia, the free encyclopedia
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| Clinical data | |
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| Trade names | Glurenorm |
| AHFS/Drugs.com | International Drug Names |
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| Routes of administration |
Oral (tablets) |
| ATC code | A10BB08 (WHO) |
| Legal status | |
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| Pharmacokinetic data | |
| Bioavailability | High (Tmax = 2–3 hours) |
| Metabolism | Extensive hepatic |
| Onset of action | 1–1.5 hours |
| Excretion | Biliary (95%), renal (5%) |
| Identifiers | |
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| CAS Number | 33342-05-1 |
| PubChem (CID) | 91610 |
| DrugBank | DB01251  |
| ChemSpider | 82719 |
| UNII | C7C2QDD75P |
| KEGG | D02430 |
| ChEMBL | CHEMBL383634 |
| ECHA InfoCard | 100.046.770 |
| Chemical and physical data | |
| Formula | C27H33N3O6S |
| Molar mass | 527.634 g/mol |
| 3D model (Jmol) | Interactive image |
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Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehringer Ingelheim (Germany).
Contraindications[edit]
- Allergy to sulfonylureas or sulfonamides
- Diabetes mellitus type 1
- Diabetic ketoacidosis
- Patients that underwent removal of the pancreas
- Acute porphyria
- Severe liver disease accompanying with liver insufficiency
- Several conditions (e.g., infectious diseases or major surgical intervention), when insulin administration is required
- Pregnancy or breastfeeding[1]
Pharmacokinetics[edit]
Gliquidone is fully metabolized by the liver. Its metabolites are excreted virtually completely with bile (even with long-term administration), thus allowing the use of medication in diabetic patients suffering from kidney disease and diabetic nephropathy.[1]
References[edit]
- ^ a b "Glurenorm (gliquidone) 30 mg Tablets, for Oral Use. Full Prescribing Information". Russian State Register of Medicinal Products (in Russian). Boehringer Ingelheim. Retrieved 12 July 2016.
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