Dihydrodeoxycorticosterone
From Wikipedia, the free encyclopedia
 |
|
| Names | |
|---|---|
| IUPAC name
(5α)-21-Hydroxypregnane-3,20-dione
|
|
| Other names
5α-Dihydro-11-deoxycorticosterone
|
|
| Identifiers | |
| 298-36-2 | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 4953958 |
| PubChem | 6451493 |
|
|
|
|
| Properties | |
| C21H32O3 | |
| Molar mass | 332.48 g·mol−1 |
|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
|
| Infobox references | |
5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.[1] It is synthesized from the adrenal hormone deoxycorticosterone (DOC) by the enzyme 5α-reductase type I.[1] DHDOC is an agonist of the progesterone receptor, as well as a positive allosteric modulator of the GABAA receptor, and is known to have anticonvulsant effects.[1][2]
See also[edit]
- Tetrahydrodeoxycorticosterone (THDOC)
- 5α-Dihydroprogesterone (DHP)
- Hydroxydione
References[edit]
- ^ a b c Reddy DS, Rogawski MA (May 2002). "Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility". J. Neurosci. 22 (9): 3795–805. PMID 11978855.
- ^ Edwards HE, Vimal S, Burnham WM (December 2005). "The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses". Epilepsia. 46 (12): 1888–97. doi:10.1111/j.1528-1167.2005.00295.x. PMID 16393154.
