Brallobarbital
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| Systematic (IUPAC) name | |
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5-(2-Bromoprop-2-en-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
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| Identifiers | |
| CAS Number | 561-86-4  |
| ATC code | none |
| PubChem | CID 68416 |
| ChemSpider | 61699 |
| UNII | D0N7A2M3MU |
| ChEMBL | CHEMBL2106093  |
| Synonyms | Brallobarbital |
| Chemical data | |
| Formula | C10H11BrN2O3 |
| Molar mass | 287.110 g/mol |
| 3D model (Jmol) | Interactive image |
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Brallobarbital is a barbiturate developed in the 1920s.[1] It has sedative and hypnotic properties, and was used for the treatment of insomnia. Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg brallobarbital and 50 mg hydroxyzine.[2] The long half-life of this combination of drugs tended to cause a hangover effect the next day,[3] and Vesparax fell into disuse once newer drugs with lesser side effects had been developed.[4]
References[edit]
- ^ US Patent 1869666
- ^ Lhermann J. Clinical application of a new very active hypnotic associating sodium secobarbital, calcium brallobarbital and hydroxyzine (UC-8130). Gazette Medicale de France. 1964 Mar 10;71:961-2. (French)
- ^ Yih TD, Rossum JM. Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Xenobiotica. 1976 Jun;6(6):355-62.
- ^ Fischbach R. Efficacy and safety of midazolam and vesparax in treatment of sleep disorders. British Journal of Clinical Pharmacology. 1983;16 Suppl 1:167S-171S.
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