Org 21465

Org 21465

Systematic (IUPAC) name
[2-[(2S,3S,5S,8S,9S,10S,13S,14S,17S)-2-(2,2-dimethylmorpholin-4-yl)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]methanesulfonate
Identifiers
PubChem	CID 10697702
Chemical data
Formula	C27H43NO7S
Molar mass	525.696
3D model (Jmol)	Interactive image
SMILES CC5(C)CN(CCO5)C2CC4(C)C(CC2O)CCC1C4C(=O)CC3(C)C1CCC3C(=O)CS(O)(=O)=O
(verify)

Org 21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABA_A receptor positive allosteric modulator. It is similar to related drugs such as Org 20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.

See also

• Org 25435