Meclonazepam
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
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(3S)-5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
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| Identifiers | |
| CAS Number | 58662-84-3  |
| ATC code | none |
| PubChem | CID 3033985 |
| ChemSpider | 2298544  |
| UNII | RN43209SMA |
| ChEMBL | CHEMBL351821 |
| Chemical data | |
| Formula | C16H12ClN3O3 |
| Molar mass | 329.74 g/mol |
| 3D model (Jmol) | Interactive image |
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Meclonazepam[1] ((S)-3-methylclonazepam) was discovered by a team at Hoffmann-La Roche in the 1970s and is a drug which is a benzodiazepine derivative similar in structure to clonazepam.[2] It has sedative and anxiolytic actions like those of other benzodiazepines,[3] and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.[4]
Meclonazepam was never used as medicine and instead appeared online as a designer drug.[5][6]
See also[edit]
References[edit]
- ^ U.S. Patent 4,031,078
- ^ The Lundbeck Institute. "Meclonazepam". Psychotropics. Lundbeck.
- ^ Ansseau, M.; Doumont, A.; Thiry, D.; Von Frenckell, R.; Collard, J. (1985). "Initial study of methylclonazepam in generalized anxiety disorder. Evidence for greater power in the cross-over design". Psychopharmacology. 87 (2): 130–135. doi:10.1007/bf00431795. PMID 3931136.
- ^ O'Boyle, C.; Lambe, R.; Darragh, A. (1985). "Central Effects in Man of the Novel Schistosomicidal Benzodiazepine Meclonazepam". European Journal of Clinical Pharmacology. 29 (1): 105–108. doi:10.1007/bf00547377. PMID 4054198.
- ^ Markus R. Meyer; Madeleine Pettersson Bergstrand; Anders Helander; Olof Beck (May 2016). "Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes". Analytical and Bioanalytical Chemistry. 408 (13): 3571–3591. doi:10.1007/s00216-016-9439-6. PMID 27071765.
- ^ Pettersson Bergstrand M, Helander A, Hansson T, Beck O (2016). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Test Anal. doi:10.1002/dta.2003. PMID 27366870.
Further reading[edit]
- Abdul-Ghani, R. A.; Loutfy, N.; Hassan, A. (2009). "Experimentally promising antischistosomal drugs: A review of some drug candidates not reaching the clinical use". Parasitology Research. 105 (4): 899–906. doi:10.1007/s00436-009-1546-2. PMID 19588166.
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