LY-344,545 is a research drug developed by the pharmaceutical company Eli Lilly , which acts as an antagonist for the metabotropic glutamate receptor subtype mGluR5 . It is an epimer of another metabotropic glutamate receptor antagonist, the mGluR2/3 -selective LY-341,495 .[1] [2]
References [ edit ]
^ Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. Journal of Medicinal Chemistry . 1998 Jan 29;41(3):358-78. PMID 9464367 ^ Doherty AJ, Palmer MJ, Bortolotto ZA, Hargreaves A, Kingston AE, Ornstein PL, Schoepp DD, Lodge D, Collingridge GL. A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices. British Journal of Pharmacology . 2000 Sep;131(2):239-44. PMID 10991916
Receptor (ligands )
AMPA
NMDA
Antagonists: Competitive antagonists: AP5 (APV) AP7 CGP-37849 CGP-39551 CGP-39653 CGP-40116 CGS-19755 CPP LY-233,053 LY-235,959 LY-274,614 MDL-100,453 Midafotel (d-CPPene) NPC-12,626 NPC-17,742 PBPD PEAQX Perzinfotel PPDA SDZ-220581 Selfotel ; Noncompetitive antagonists: ARR-15,896 Caroverine Dexanabinol FPL-12495 FR-115,427 Hodgkinsine Magnesium MDL-27,266 NPS-1506 Psychotridine Zinc ; Uncompetitive pore blockers: 2-MDP 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 4-MeO-PCP 8A-PDHQ 18-MC α-Endopsychosin Alaproclate Amantadine Aptiganel Arketamine ARL-12,495 ARL-15,896-AR ARL-16,247 Budipine Conaridine Delucemine Dexoxadrol Dextrallorphan Dieticyclidine Diphenidine Dizocilpine Ephenidine Esketamine Etoxadrol Eticyclidine Fluorolintane Gacyclidine Ibogaine Ibogamine Indantadol Ketamine Ketobemidone Lanicemine Loperamide Memantine Methadone (Levomethadone )Methorphan (Dextromethorphan Levomethorphan )Methoxetamine Methoxphenidine Milnacipran Morphanol (Dextrorphan Levorphanol )NEFA Neramexane Nitromemantine Nitrous oxide Noribogaine Norketamine Orphenadrine PCPr Pethidine (meperidine) Phencyclamine Phencyclidine Propoxyphene Remacemide Rhynchophylline Rimantadine Rolicyclidine Sabeluzole Tabernanthine Tenocyclidine Tiletamine Tramadol Xenon ; Glycine site antagonists: 4-Cl-KYN (AV-101) 5,7-DCKA 7-CKA ACC ACEA-1011 ACEA-1328 AV-101 Carisoprodol CGP-39653 CNQX DNQX Felbamate Gavestinel GV-196,771 Kynurenic acid Kynurenine L-689,560 L-701,324 Licostinel (ACEA-1021) LU-73,068 MDL-105,519 Meprobamate MRZ 2/576 PNQX ZD-9379 ; NR2B subunit antagonists: Besonprodil CERC-301 (MK-0657) CO-101,244 (PD-174,494) Eliprodil Haloperidol Ifenprodil Isoxsuprine Nylidrin Ro8-4304 Ro25-6981 Traxoprodil ; Polyamine site antagonists: Arcaine Co 101676 Diaminopropane Diethylenetriamine Huperzine A Putrescine Ro 25-6981 ; Unclassified/unsorted antagonists: Bumetanide Chloroform Cyclopropane D -αAADiethyl ether Enflurane Ethanol Flufenamic acid Flupirtine Furosemide Halothane Isoflurane Metaphit Methoxyflurane Niflumic acid Pentamidine isethionate Piretanide Toluene Transcrocetin (saffron )Trichloroethane Trichloroethanol Trichloroethylene Xylene
Kainate
mGlu1
mGlu2
mGlu3
mGlu4
mGlu5
mGlu6
mGlu7
mGlu8
Transporter (blockers )
Enzyme (inhibitors )
Others
