Tribendimidine

Tribendimidine
Clinical data
ATC code	none
Identifiers
CAS Number	115103-15-6
PubChem	CID 3086564
ChemSpider	2343161
ChEMBL	CHEMBL427256
Chemical and physical data
	'Systematic (IUPAC) name: N,N-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4; -phenylene dimethylidyneamine
3D model (Jmol)	Interactive image
Formula	C28H32N6
Molar mass	452.594 g/mol
	SMILES N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)cc2)\c3ccc(\N=C(\N(C)C)C)cc3 ;
	InChI InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+ ; Key:XOIOGKHKNQYULW-HTNNXBMUSA-N ;
(what is this?) (verify)

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.^[1]

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.^[2] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.^[1]

References[edit]

^ ^a ^b Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrob Agents Chemother. 51 (3): 1096–8. doi:10.1128/AAC.01366-06. PMC 1803157. PMID 17194822. Free full text.
^ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Trop. 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.