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'Don't let Donald Trump find out': Ellen Pompeo jokes she doesn't want new US President to know she's 'practicing fake medicine' on Grey's Anatomy

Published: 00:14 EST, 26 January 2017 | Updated: 03:13 EST, 26 January 2017

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Grey's Anatomy's Ellen Pompeo is bringing a bit of playfulness to her politics.

The outspoken 47-year-old actress tweeted a tongue-in-cheek shot at President Donald Trump Wednesday, a day after the commander-in-chief took to Twitter to jab at one of his least-favorite media outlets, CNN.

She has played Dr. Meredith Grey on Shonda Rhimes' ABC drama for more than a decade.

Not really a doctor: Ellen Pompeo, who plays Dr. Meredith Grey on Grey's Anatomy, joked she didn't want President Donald Trump knowing she's a practitioner of 'fake medicine' amid the commander-in-chief's repeated remarks about 'fake news'

A sense of humor: The politically-charged actress took to Twitter to razz the president

On his fifth day in the oval office, The Celebrity Apprentice host on Tuesday tweeted: 'Congratulations to Fox News for being number one in inauguration ratings. They were many times higher than FAKE NEWS CNN - public is smart!'

Pompeo, who's been outspoken in her criticism of the U.S.'s 45th president, replied with a reference to her TV alter ego.

'Please God don't let Donald Trump find out I'm practicing fake medicine every week,' she tweeted with an emoji of two hands in prayer, and a GIF of rapper Drake looking to the heavens.

The accomplished actress, in a tongue-in-cheek nod to Trump's bitter response to Meryl Streep's Golden Globes speech, added the hashtag, '#imoverratedanyway.'

On the go: The successful actress was snapped in her native LA last week

Consistent: Trump has continued to engage in Twitter battles after being sworn in to the oval office

Also speaking on Trump Wednesday, Pompeo said she believed Trump's repeated complaints about the way the votes were tallied in the 2016 election serve as 'a smokescreen to abolish voting rights act ... so [he and his allies] can secure their position in the midterm elections.'

The actress last Thursday and her husband of ten years, Chris Ivery enjoyed a parents' night out to attend the unveiling of The Century Plaza Hotel & Residence just a few weeks after welcoming their third child.

She looked smart and slender in a dark pea-coat as she posed alongside her music producer beau, 50, upon arrival at the location of the iconic landmark that will be undergoing a $2.5 billion redevelopment.

Parents' night out: Thursday, Ellen Pompeo and husband Chris Ivery attended the unveiling of The Century Plaza Hotel just a few weeks after welcoming their third child

The Catch Me If You Can actress was demure in all black, wearing sleek black pants and matching top.

She hid from the LA chill beneath a knee-length black pea coat and rocked a pair of suede black pointed-toe pumps.

Her ombred light brown-and-blonde locks were fashioned into a straight-with-body bedhead style and her makeup was light and fresh.

Low-maintenance: The Catch Me If You Can actress was demure in all black, wearing sleek black pants and matching top

Looking good: Ellen's husband was dapper in a black two-piece suit, a crispy white button-down, a black tie and fresh black-and-white slip on sneakers

New daddy: Ellen took to Instagram to announce the birth, posting a sweet photo of her husband and son

Ellen's husband was dapper in a black two-piece suit, a crispy white button-down, a black tie and fresh black-and-white slip on sneakers.

The husband-wife team enjoyed their night out after Grey's Anatomy won Favorite Network TV Drama at the People's Choice Awards on Wednesday and after welcoming their first son, Eli Christopher, at the end of December.

Ellen took to Instagram to announce the birth, posting a sweet photo of her husband and son and captioning it: '❤️Eli Christopher❤️ Chris Ivery just fell a notch.. I've got a new guy.'

Star-studded: The couple shared the carpet with actors Darren Criss and Josh Duhamel

On their Thursday night outing, the couple shared the carpet with actors Darren Criss and Josh Duhamel, who also showed up to be wowed by the unveiling of the redevelopment of the landmark Century Plaza Hotel.

The project - which has been described as 'an elevated level of living' and 'the centerpiece of the future of our city' - has been in talks for nearly a decade, but construction only began at the end of 2016.

The reconstruction will build upon the historic design by Minoru Yamaski and will convert the upper floors of the 16-story building into 63 condominiums and will retain 400 hotel rooms and 93,000 square feet of commercial spaces on its lower levels, according to Urbanize.LA.