Thonzylamine

Thonzylamine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	D04AA01 (WHO) R01AC06 (WHO) R06AC06 (WHO)
Identifiers
	IUPAC name N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine;
Synonyms	Neohetramine
CAS Number	91-85-0 63-56-9
PubChem (CID)	5457
ChemSpider	5258
UNII	R79646H5Z8
KEGG	D08587
ChEMBL	CHEMBL1623738
ECHA InfoCard	100.001.913
Chemical and physical data
Formula	C16H22N4O
Molar mass	286.372 g/mol
3D model (Jmol)	Interactive image
	SMILES n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2 ;
	InChI InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 ; Key:GULNIHOSWFYMRN-UHFFFAOYSA-N ;
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Thonzylamine (or neohetramine)^[1] is an antihistamine and anticholinergic used as an antipruritic.

Synthesis[edit]

Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, U.S. Patent 2,465,865 (1949).

^ Arminio, J. J.; Sweet, C. C. (1949). "The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride)". Industrial medicine & surgery. 18 (12): 509–511. PMID 15393969.

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v t e Antipruritics (D04)

Antihistamines for topical use	Thonzylamine Mepyramine Thenalidine Tripelennamine Chloropyramine Promethazine Tolpropamine Dimetindene Clemastine Bamipine Isothipendyl Diphenhydramine Chlorphenoxamine

Anesthetics for topical use	Lidocaine Dibucaine Oxybuprocaine Benzocaine Quinisocaine Tetracaine Pramocaine

Others	Corticosteroids (e.g., hydrocortisone) Counterirritants (e.g., mint oil, menthol, camphor) Nalfurafine

v t e Antihistamines (R06)

Aminoalkyl ethers	Bromazine (bromodiphenhydramine) Carbinoxamine Clemastine Chlorphenoxamine Diphenylpyraline Diphenhydramine Doxylamine Orphenadrine Phenyltoloxamine

Substituted alkylamines	Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Dimetindene Pheniramine Talastine

Substituted ethylenediamines	Chloropyramine Histapyrrodine Mepyramine Methapyrilene Tripelennamine (pyribenzamine)

Phenothiazine derivatives	Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine

Piperazine derivatives	Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Hydroxyzine Meclizine Oxatomide

Others for systemic use	Antazoline Azanator Azatadine Bamipine Cyproheptadine Deptropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Mebhydrolin Mizolastine Olopatadine Phenindamine Pimethixene Pyrrobutamine Quifenadine Rupatadine Triprolidine selective (Acrivastine Astemizole Azelastine Bilastine Desloratadine Fexofenadine Loratadine Terfenadine)

For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Isothipendyl Mepyramine Promethazine Thenalidine