FZD8

FZD8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IJY, 4F0A
Identifiers
Aliases	FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs	MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
Gene ontology Molecular function • transmembrane signaling receptor activity • receptor binding • ubiquitin protein ligase binding • Wnt-protein binding • protein binding • signal transducer activity • G-protein coupled receptor activity • Wnt-activated receptor activity • PDZ domain binding Cellular component • integral component of membrane • membrane • plasma membrane • Golgi apparatus • Wnt-Frizzled-LRP5/6 complex Biological process • positive regulation of protein phosphorylation • positive regulation of JUN kinase activity • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • angiogenesis • positive regulation of transcription from RNA polymerase II promoter • multicellular organism development • negative regulation of transcription from RNA polymerase II promoter • non-canonical Wnt signaling pathway • canonical Wnt signaling pathway • neuron differentiation • signal transduction • Wnt signaling pathway • T cell differentiation in thymus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8325	14370
Ensembl	ENSG00000177283	ENSMUSG00000036904
UniProt	Q9H461	Q61091
RefSeq (mRNA)	NM_031866	NM_008058
RefSeq (protein)	NP_114072	NP_032084.2
Location (UCSC)	Chr 10: 35.64 – 35.64 Mb	Chr 18: 9.21 – 9.22 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

See also

• Frizzled

Further reading

• Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. doi:10.1074/jbc.271.8.4468. PMID 8626800. 
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. 
• Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. doi:10.1038/35035117. PMID 11029007. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
• Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. 
• Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature. 412 (6842): 86–90. doi:10.1038/35083601. PMID 11452312. 
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. doi:10.1006/bbrc.2001.5430. PMID 11520064. 
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. 
• Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084. 

External links

• "Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.