FZD5

FZD5
Identifiers
Aliases	FZD5, C2orf31, HFZ5, frizzled class receptor 5
External IDs	MGI: 108571 HomoloGene: 2590 GeneCards: FZD5
Gene ontology Molecular function • G-protein coupled receptor activity • beta-amyloid binding • signal transducer activity • Wnt-protein binding • protein binding • protein kinase binding • ubiquitin protein ligase binding • transmembrane signaling receptor activity • Wnt-activated receptor activity Cellular component • integral component of membrane • clathrin-coated endocytic vesicle membrane • Golgi apparatus • early endosome membrane • membrane • bicellular tight junction • Golgi membrane • plasma membrane • cell surface • early endosome • perinuclear region of cytoplasm Biological process • G-protein coupled receptor signaling pathway • non-canonical Wnt signaling pathway • T cell differentiation in thymus • chorionic trophoblast cell differentiation • positive regulation of protein targeting to mitochondrion • positive regulation of JUN kinase activity • apoptotic process involved in morphogenesis • regulation of chorionic trophoblast cell proliferation • regulation of bicellular tight junction assembly • regulation of canonical Wnt signaling pathway • cellular response to molecule of bacterial origin • positive regulation of interferon-gamma production • embryonic axis specification • labyrinthine layer blood vessel development • cell maturation • Wnt signaling pathway • embryonic camera-type eye development • multicellular organism development • cell surface receptor signaling pathway • vasculature development • regulation of mitophagy • branching involved in labyrinthine layer morphogenesis • embryonic camera-type eye morphogenesis • post-embryonic camera-type eye development • positive regulation of T cell cytokine production • angiogenesis • neuron differentiation • Wnt signaling pathway involved in dorsal/ventral axis specification • canonical Wnt signaling pathway • synapse assembly • syncytiotrophoblast cell differentiation involved in labyrinthine layer development • anterior/posterior axis specification, embryo • Spemann organizer formation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • signal transduction • Wnt signaling pathway, calcium modulating pathway • Wnt signaling pathway, planar cell polarity pathway • beta-catenin destruction complex disassembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7855	14367
Ensembl	ENSG00000163251	ENSMUSG00000045005
UniProt	Q13467	Q9EQD0
RefSeq (mRNA)	NM_030804 NM_003468	NM_001033193 NM_001042659 NM_022721
RefSeq (protein)	NP_003459	NP_001036124.1 NP_073558.2
Location (UCSC)	Chr 2: 207.76 – 207.77 Mb	Chr 1: 64.73 – 64.74 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• He X, Saint-Jeannet JP, Wang Y, et al. (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A.". Science. 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID 9054360. 
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. 
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
• Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction.". Nature. 407 (6803): 530–5. doi:10.1038/35035117. PMID 11029007. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. 
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Weidler C, Schaumburger J, Miller LE, et al. (2004). "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.". J. Rheumatol. 31 (9): 1874–5. PMID 15338479. 
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. 
• Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.". Biochem. Biophys. Res. Commun. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Blumenthal A, Ehlers S, Lauber J, et al. (2006). "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.". Blood. 108 (3): 965–73. doi:10.1182/blood-2005-12-5046. PMID 16601243. 
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161. 
• Katoh Y, Katoh M (2007). "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.". Int. J. Oncol. 30 (3): 751–5. doi:10.3892/ijo.30.3.751. PMID 17273778. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.