Portal:Biological warfare

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Biological warfare Portal

Biological warfare (BW), also known as germ warfare, is the use of pathogens such as viruses, bacteria, other disease-causing biological agents, or the toxins produced by them as biological weapons (or bioweapons). There is a clear overlap between biological warfare and chemical warfare, as the use of toxins produced by living organisms is considered under the provisions of both the Biological and Toxin Weapons Convention and the Chemical Weapons Convention. Toxins, which are of organic origin, are often called "midspectrum agents". A biological weapon may be intended to kill, incapacitate, or seriously impair a person, group of people, or even an entire population. It may also be defined as the material or defense against such employment. Biological warfare is a military technique that can be used by nation-states or non-national groups. In the latter case, or if a nation-state uses it clandestinely, it may also be considered bioterrorism.The Geneva convention restricts the use of biological and chemical weapons as it is against human rights to use them.

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Insulin crystals
Biotechnology is technology based on biology, agriculture, food science, and medicine. Modern use of the term usually refers to genetic engineering as well as cell- and tissue culture technologies. However, the concept encompasses a wider range and history of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of plants and "improvements" to these through breeding programs that employ artificial selection and hybridization. By comparison to biotechnology, bioengineering is generally thought of as a related field with its emphasis more on mechanical and higher systems approaches to interfacing with and exploiting living things. United Nations Convention on Biological Diversity defines biotechnology as: "Any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use." Biotechnology draws on the pure biological sciences (genetics, microbiology, animal cell culture, molecular biology, biochemistry, embryology, cell biology) and in many instances is also dependent on knowledge and methods from outside the sphere of biology (chemical engineering, bioprocess engineering, information technology, biorobotics). Conversely, modern biological sciences (including even concepts such as molecular ecology) are intimately entwined and dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry.

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M33 cluster bomb
Credit: Chemical and Biological Defense Command Historical Research and Response Team

The M33 cluster bomb, also known as the (M33) Brucella cluster bomb, was a U.S. biological cluster bomb developed in the early 1950s and deployed in 1952. It was the first standardized biological weapon in the U.S. arsenal.

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Prion
A prion is an infectious agent that is composed primarily of protein. To date, all such agents that have been discovered propagate by transmitting a mis-folded protein state; the protein itself does not self-replicate and the process is dependent on the presence of the polypeptide in the host organism. The mis-folded form of the prion protein has been implicated in a number of diseases in a variety of mammals, including bovine spongiform encephalopathy (BSE, also known as "mad cow disease") in cattle and Creutzfeldt–Jakob disease (CJD) in humans. All known prion diseases affect the structure of the brain or other neural tissue, and all are currently untreatable and are always fatal. In general usage, prion refers to the theoretical unit of infection. In scientific notation, PrPC refers to the endogenous form of prion protein (PrP), which is found in a multitude of tissues, while PrPSc refers to the misfolded form of PrP, that is responsible for the formation of amyloid plaques and neurodegeneration. Prions are hypothesized to infect and propagate by refolding abnormally into a structure which is able to convert normal molecules of the protein into the abnormally structured form. All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly packed beta sheets. This altered structure is extremely stable and accumulates in infected tissue, causing tissue damage and cell death. This stability means that prions are resistant to denaturation by chemical and physical agents, making disposal and containment of these particles difficult. Proteins showing prion-type behavior are also found in some fungi, which has been useful in helping to understand mammalian prions. Fungal prions, however, do not appear to cause disease in their hosts and may even confer an evolutionary advantage through a form of protein-based inheritance. The word prion is a compound word derived from the initial and final letters of the words proteinaceous and infection.

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Encephalitis

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Bacillus anthracis from Aum Shinrikyo bioterrorism incident, Kameido, Tokyo, 1993
On March 20, 1995, members of the Aum Shinrikyo cult entered the Tokyo subway system and released sarin, a deadly nerve agent. The subway attack was the most deadly assault in an ongoing campaign of terror waged by this mysterious cult. ... Chemical weapons were not, however, the only option available to the Aum. The first cult laboratory for toxin production was actually in place by 1990 and was subsequently replaced with two new laboratories, one at Kamakuishki and the other in Tokyo. Aum dabbled in many different biological agents. They cultured and experimented with botulin toxin, anthrax, cholera, and Q fever. In 1993, Ashahara led a group of 16 cult doctors and nurses to Zaire, on a supposed medical mission. The actual purpose of the trip to Central Africa was to learn as much as possible about and, ideally, to bring back samples of Ebola virus. In early 1994, cult doctors were quoted on Russian radio as discussing the possibility of using Ebola as a biological weapon.

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