Watch on LabRoots at http://www.labroots.com/webcast/impulse-control-disorders-behavioural-addictions-insights-from-dopaminergic-medication-related-behaviours-in-parkinson-s-disease Impulse control disorders (ICDs), also known as behavioural addictions, are common in the general population and can have marked consequences.  ICDs can also commonly occur with exposure to dopamine agonists and Levodopa used in the treatment of Parkinson’s disease and provide an intriguing pathophysiological insight.  These behaviours include pathological gambling, compulsive sexual behaviors, binge eating and compulsive shopping.  That the behaviours only occur in a subset of individuals argues for an interaction between the exogenous dopaminergic activity and either an individual vulnerability for addictions or a role for Parkinson’s disease.  Here I discuss evidence from rodent and human studies that chronic exogenous dopamine may interfere with physiological functions of dopamine and link preclinical and clinical data.  Where relevant I compare with behavioural and substance addictions in the general population.    Enhanced ventral striatal dopaminergic activity is observed within specific contexts; this may be related to decreases in striatal dopamine transporter levels and presynaptic D2 autoreceptor sensitivity enhancing physiological dopaminergic activity or chronic Levodopa increasing dopaminergic gain.  Chronic D2 receptor stimulation is hypothesized to impair detection of negative prediction errors.  Converging evidence highlights the relative imbalance of ventral and dorsal striatal systems.  The reinforcing properties of dopaminergic medications are enhanced in rodent parkinsonian models.   In humans, this imbalance is captured in the better fit with ventral striatal critic models reliant on stimulus value rather than dorsal striatal actor models.  Greater impulsivity in the decisional rather than the motoric domain further reinforces this imbalance.  Stimulation of the subthalamic nucleus appears to moderate these behaviours, likely related to changes in dopaminergic medications but also possibly to an influence on cognitive mechanisms.  Understanding mechanisms underlying dopaminergic medication-induced ICDs provides critical insights into the role of dopamine on cognitive processes and the emerging conceptualization of behavioural addictions.   Learning goals: To understand the role of exogenous dopamine on cognitive processes To facilitate a discussion between similarities and differences of these behaviours and behavioural and substance addictions in the general population.

• published: 18 Mar 2016
• views: 819