IRX4

IRX4
Identifiers
Aliases	IRX4, IRXA3, iroquois homeobox 4
External IDs	MGI: 1355275 HomoloGene: 9485 GeneCards: IRX4
Genetically Related Diseases
cardiovascular system disease
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding Cellular component • nucleus Biological process • heart development • regulation of transcription, DNA-templated • establishment of animal organ orientation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50805	50916
Ensembl	ENSG00000113430	ENSMUSG00000021604
UniProt	P78413	Q9QY61
RefSeq (mRNA)	NM_016358 NM_001278632 NM_001278633 NM_001278634 NM_001278635	NM_018885
RefSeq (protein)	NP_001265561 NP_001265562 NP_001265563 NP_001265564 NP_057442	NP_061373.1
Location (UCSC)	Chr 5: 1.88 – 1.89 Mb	Chr 13: 73.26 – 73.27 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.

Further reading

• Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142. 
• Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression.". J. Biol. Chem. 276 (31): 28835–41. doi:10.1074/jbc.M103716200. PMID 11382777. 
• Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy.". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553. 
• Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests.". European Journal of Human Genetics. 18 (7): HASH(0x24ee8d0). doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.