SCN7A

SCN7A
Identifiers
Aliases	SCN7A, NaG, Nav2.1, Nav2.2, SCN6A, sodium voltage-gated channel alpha subunit 7
External IDs	MGI: 102965 HomoloGene: 55706 GeneCards: SCN7A
Gene ontology Molecular function • ion channel activity • sodium channel activity • voltage-gated sodium channel activity • voltage-gated ion channel activity Cellular component • voltage-gated sodium channel complex • integral component of membrane • glial cell projection • plasma membrane • membrane Biological process • regulation of ion transmembrane transport • sodium ion homeostasis • muscle contraction • membrane depolarization during action potential • ion transport • sodium ion transmembrane transport • transmembrane transport • neuronal action potential • sodium ion transport • transport • ion transmembrane transport • regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6332	20272
Ensembl	ENSG00000136546	ENSMUSG00000034810
UniProt	Q01118	n/a
RefSeq (mRNA)	NM_002976	NM_009135
RefSeq (protein)	NP_002967.2	n/a
Location (UCSC)	Chr 2: 166.4 – 166.49 Mb	Chr 2: 66.67 – 66.78 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome specifically located at 2q21-23 chromosome site. This is one of 10 Sodium channel types, and is expressed in the heart, the uterus and in glial cells. Its sequence identity is 48, and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin).

See also

• Sodium channel

Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Na_x (also known as NaG, Na_v2.1, etc.) It belongs to a family of Sodium Channel known as Voltage-Gated, but is not activated by changes in the membrane's voltage, as happen usually in the members of this family (Na_v1.1 to Na_v1.9); it activates by changes in the extracellular concentration of sodium [~150 mM].

Further reading

• Noda M, Hiyama TY (2015). "The Nax Channel: What It Is and What It Does". Neuroscientist. 21 (4): 399–412. doi:10.1177/1073858414541009. PMID 24962095. 
• Hiyama TY, Yoshida M, Matsumoto M, et al. (2013). "Endothelin-3 expression in the subfornical organ enhances the sensitivity of Nax, the brain sodium-level sensor, to suppress salt intake". Cell Metab. 17 (4): :507–19. doi:10.1016/j.cmet.2013.02.018. PMID 23541371. 
• Shimizu H, Watanabe E, Hiyama TY, et al. (2007). "Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing". Neuron. 54 (1): 59–72. doi:10.1016/j.neuron.2007.03.014. PMID 17408578. 
• Hiyama TY, Watanabe E, et al. (2004). "The subfornical organ is the primary locus of sodium-level sensing by Nax sodium channels for the control of salt-intake behavior.". J Neurosci. 24 (42): 9276–81. doi:10.1523/JNEUROSCI.2795-04.2004. PMID 15496663. 
• Meyers KJ, Mosley TH, Fox E, et al. (2007). "Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks". Hypertension. 49 (5): 992–9. doi:10.1161/HYPERTENSIONAHA.106.081265. PMID 17339538. 
• Zhang KX, Zhu DL, He X, et al. (2004). "[Association of single nucleotide polymorphism in human SCN7A gene with essential hypertension in Chinese]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 20 (6): 463–7. PMID 14669210. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Goldin AL, Barchi RL, Caldwell JH, et al. (2001). "Nomenclature of voltage-gated sodium channels". Neuron. 28 (2): 365–8. doi:10.1016/S0896-6273(00)00116-1. PMID 11144347. 
• Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• George AL, Knops JF, Han J, et al. (1994). "Assignment of a human voltage-dependent sodium channel alpha-subunit gene (SCN6A) to 2q21-q23". Genomics. 19 (2): 395–7. doi:10.1006/geno.1994.1081. PMID 8188276. 
• Boyle MB; Heslip LA (1995). "Voltage-dependent Na+ channel mRNA expression in pregnant myometrium". Recept. Channels. 2 (3): 249–53. PMID 7874451. 
• Han JA; Lu CM; Brown GB; Rado TA (1991). "Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 335–9. doi:10.1073/pnas.88.2.335. PMC 50805. PMID 1846440. 
• George AL; Knittle TJ; Tamkun MM (1992). "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family". Proc. Natl. Acad. Sci. U.S.A. 89 (11): 4893–7. doi:10.1073/pnas.89.11.4893. PMC 49194. PMID 1317577. 

External links

• SCN7A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.