KCNB1

KCNB1
Identifiers
Aliases	KCNB1, DRK1, KV2.1, h-DRK1, EIEE26, potassium voltage-gated channel subfamily B member 1
External IDs	MGI: 96666 HomoloGene: 37988 GeneCards: KCNB1
Genetically Related Diseases
obesity
Targeted by Drug
linoleic acid
Gene ontology Molecular function • potassium channel activity • ion channel binding • ubiquitin-like protein binding • voltage-gated ion channel activity • ion channel activity • protein binding • protein heterodimerization activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity Cellular component • integral component of membrane • perikaryon • postsynaptic membrane • cell projection • lateral plasma membrane • membrane • voltage-gated potassium channel complex • plasma membrane • synapse • axon • cell junction • dendrite • neuron projection • sarcolemma • intracellular • neuronal cell body membrane Biological process • exocytosis • positive regulation of norepinephrine secretion • glutamate receptor signaling pathway • regulation of insulin secretion • regulation of ion transmembrane transport • positive regulation of catecholamine secretion • ion transport • vesicle docking involved in exocytosis • protein targeting to plasma membrane • positive regulation of calcium ion-dependent exocytosis • potassium ion transport • regulation of motor neuron apoptotic process • transmembrane transport • cellular response to nutrient levels • potassium ion transmembrane transport • transport • action potential • protein homooligomerization • positive regulation of protein targeting to membrane • positive regulation of long term synaptic depression • regulation of action potential • negative regulation of insulin secretion • glucose homeostasis • cellular response to glucose stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3745	16500
Ensembl	ENSG00000158445	ENSMUSG00000050556
UniProt	Q14721	Q03717
RefSeq (mRNA)	NM_004975	NM_008420
RefSeq (protein)	NP_004966.1	NP_032446.2
Location (UCSC)	Chr 20: 49.36 – 49.48 Mb	Chr 2: 167.1 – 167.19 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Potassium voltage-gated channel, Shab-related subfamily, member 1, also known as KCNB1 or K_v2.1, is a protein that, in humans, is encoded by the KCNB1 gene.

Species and tissue distribution

K_v2.1 channels are widely expressed in various tissues in mammals, including humans. They are found in cardiomyocytes, skeletal muscles, vascular smooth muscles, placental vasculature, retina, and pancreatic β-cells.

Function

Voltage-gated potassium (K_v) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

In mouse cardiomyocytes, K_v2.1 channel is the molecular substrate of major repolarization current I_K-slow2. Transgenic mice, expressing a dominant-negative isoform of K_v2.1, exhibit markedly prolonged action potentials and demonstrate arrhythmia. In mammalian CNS neurons, K_v2.1 is a predominant delayed rectifier K⁺ current that regulates neuronal excitability, action potential duration, and tonic spiking. In Drosophila photoreceptor cells, the K_v2 channel is the key component of light-induced membrane voltage response. Genetic abolition of this current dramatically decreases photoreceptor information capacity.

Interactions

KCNB1 has been shown to interact with:

• KCNH1, and
• PTPRE.

See also

• Voltage-gated potassium channel
• Guangxitoxin

Further reading

• Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
• Melis R, Stauffer D, Zhao X, et al. (1995). "Physical and genetic localization of a Shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2". Genomics. 25 (1): 285–7. doi:10.1016/0888-7543(95)80138-C. PMID 7774931. 
• Albrecht B, Lorra C, Stocker M, Pongs O (1994). "Cloning and characterization of a human delayed rectifier potassium channel gene". Recept. Channels. 1 (2): 99–110. PMID 8081723. 
• Hugnot JP, Salinas M, Lesage F, et al. (1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. PMC 451895. PMID 8670833. 
• Post MA, Kirsch GE, Brown AM (1997). "Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current". FEBS Lett. 399 (1–2): 177–82. doi:10.1016/S0014-5793(96)01316-6. PMID 8980147. 
• Patel AJ, Lazdunski M, Honoré E (1998). "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes". EMBO J. 16 (22): 6615–25. doi:10.1093/emboj/16.22.6615. PMC 1170266. PMID 9362476. 
• Shepard AR, Rae JL (1999). "Electrically silent potassium channel subunits from human lens epithelium". Am. J. Physiol. 277 (3 Pt 1): C412–24. PMID 10484328. 
• Zhu XR, Netzer R, Böhlke K, et al. (1999). "Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel". Recept. Channels. 6 (5): 337–50. PMID 10551266. 
• Peretz A, Gil-Henn H, Sobko A, et al. (2000). "Hypomyelination and increased activity of voltage-gated K+ channels in mice lacking protein tyrosine phosphatase ε". EMBO J. 19 (15): 4036–45. doi:10.1093/emboj/19.15.4036. PMC 306594. PMID 10921884. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Sano Y, Mochizuki S, Miyake A, et al. (2002). "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1". FEBS Lett. 512 (1–3): 230–4. doi:10.1016/S0014-5793(02)02267-6. PMID 11852086. 
• Kurata HT, Soon GS, Eldstrom JR, et al. (2002). "Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels". J. Biol. Chem. 277 (32): 29045–53. doi:10.1074/jbc.M111470200. PMID 12021261. 
• Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986–91. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745. 
• MacDonald PE, Wang G, Tsuk S, et al. (2003). "Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus". Mol. Endocrinol. 16 (11): 2452–61. doi:10.1210/me.2002-0058. PMID 12403834. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ju M, Stevens L, Leadbitter E, Wray D (2003). "The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel". J. Biol. Chem. 278 (15): 12769–78. doi:10.1074/jbc.M212973200. PMID 12560340. 
• Tiran Z, Peretz A, Attali B, Elson A (2003). "Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon". J. Biol. Chem. 278 (19): 17509–14. doi:10.1074/jbc.M212766200. PMID 12615930. 
• Consiglio JF, Korn SJ (2004). "Influence of Permeant Ions on Voltage Sensor Function in the Kv2.1 Potassium Channel". J. Gen. Physiol. 123 (4): 387–400. doi:10.1085/jgp.200308976. PMC 2217458. PMID 15024041. 
• Thébaud B, Michelakis ED, Wu XC, et al. (2005). "Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus". Circulation. 110 (11): 1372–9. doi:10.1161/01.CIR.0000141292.28616.65. PMID 15353504. 
• Kerschensteiner D, Soto F, Stocker M (2005). "Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier α-subunits". Proc. Natl. Acad. Sci. U.S.A. 102 (17): 6160–5. doi:10.1073/pnas.0500468102. PMC 1087924. PMID 15827117. 

External links

• Kv2.1 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.