GJA4

GJA4
Identifiers
Aliases	GJA4, CX37, gap junction protein alpha 4
External IDs	MGI: 95715 HomoloGene: 1556 GeneCards: GJA4
Targeted by Drug
carbenoxolone, flufenamic acid, caprylic alcohol
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • gap junction • cell junction • plasma membrane • integral component of plasma membrane • connexin complex • membrane Biological process • cell communication • cell-cell signaling • blood vessel development • response to pain • calcium ion transport • cell-cell junction assembly • endothelium development • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2701	14612
Ensembl	ENSG00000187513	ENSMUSG00000050234
UniProt	P35212	P28235
RefSeq (mRNA)	NM_002060	NM_008120
RefSeq (protein)	NP_002051.2	NP_032146.1
Location (UCSC)	Chr 1: 34.79 – 34.8 Mb	Chr 4: 127.31 – 127.31 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Gap junction alpha-4 protein is a protein that in humans is encoded by the GJA4 gene.

Further reading

• Andrew L Harris; Darren Locke (2009). Connexins, A Guide. New York: Springer. p. 574. ISBN 978-1-934115-46-6. 
• Beyer EC, Paul DL, Goodenough DA (1990). "Connexin family of gap junction proteins". J. Membr. Biol. 116 (3): 187–94. doi:10.1007/BF01868459. PMID 2167375. 
• Haefliger JA, Bruzzone R, Jenkins NA, et al. (1992). "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping". J. Biol. Chem. 267 (3): 2057–64. PMID 1370487. 
• Risek B, Guthrie S, Kumar N, Gilula NB (1990). "Modulation of gap junction transcript and protein expression during pregnancy in the rat". J. Cell Biol. 110 (2): 269–82. doi:10.1083/jcb.110.2.269. PMC 2116004. PMID 1688855. 
• Willecke K, Jungbluth S, Dahl E, et al. (1991). "Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes". Eur. J. Cell Biol. 53 (2): 275–80. PMID 1964417. 
• Van Camp G, Coucke P, Speleman F, et al. (1996). "The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195". Genomics. 30 (2): 402–3. PMID 8586454. 
• Krutovskikh V, Mironov N, Yamasaki H (1996). "Human connexin 37 is polymorphic but not mutated in tumours". Carcinogenesis. 17 (8): 1761–3. doi:10.1093/carcin/17.8.1761. PMID 8761439. 
• Simon AM, Goodenough DA, Li E, Paul DL (1997). "Female infertility in mice lacking connexin 37". Nature. 385 (6616): 525–9. doi:10.1038/385525a0. PMID 9020357. 
• Krenacs T, Rosendaal M (1998). "Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation". Am. J. Pathol. 152 (4): 993–1004. PMC 1858239. PMID 9546360. 
• van Rijen HV, van Kempen MJ, Postma S, Jongsma HJ (1998). "Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells". Cytokine. 10 (4): 258–64. doi:10.1006/cyto.1997.0287. PMID 9617570. 
• Boerma M, Forsberg L, Van Zeijl L, et al. (1999). "A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development". J. Intern. Med. 246 (2): 211–8. doi:10.1046/j.1365-2796.1999.00564.x. PMID 10447790. 
• Saito T, Krutovskikh V, Marion MJ, et al. (2000). "Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene". Int. J. Cancer. 86 (1): 67–70. doi:10.1002/(SICI)1097-0215(20000401)86:1<67::AID-IJC10>3.0.CO;2-1. PMID 10728596. 
• Suzuki Y, Taira H, Tsunoda T, et al. (2001). "Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites". EMBO Rep. 2 (5): 388–93. doi:10.1093/embo-reports/kve085. PMC 1083880. PMID 11375929. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Tsai MY, Lan KC, Huang KE, et al. (2004). "Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles". Fertil. Steril. 80 (6): 1437–43. doi:10.1016/j.fertnstert.2003.05.015. PMID 14667880. 
• Seul KH, Kang KY, Lee KS, et al. (2004). "Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis". Biochem. Biophys. Res. Commun. 319 (4): 1144–51. doi:10.1016/j.bbrc.2004.05.097. PMID 15194487. 
• Kameritsch P, Khandoga N, Nagel W, et al. (2005). "Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules". J. Cell. Physiol. 203 (1): 233–42. doi:10.1002/jcp.20218. PMID 15481066. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.