CatSper2

CATSPER2
Identifiers
Aliases	CATSPER2, CatSper2
External IDs	MGI: 2387404 HomoloGene: 77423 GeneCards: CATSPER2
Targeted by Drug
alprostadil, dinoprostone, progesterone, mibefradil
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium activated cation channel activity • calcium channel activity • voltage-gated ion channel activity • ion channel activity • protein binding Cellular component • integral component of membrane • CatSper complex • cell projection • membrane • plasma membrane • cilium • motile cilium Biological process • flagellated sperm motility • cell differentiation • membrane depolarization during action potential • regulation of ion transmembrane transport • ion transport • multicellular organism development • calcium ion transmembrane transport • transmembrane transport • spermatogenesis • sperm-egg recognition • transport • calcium ion transport • response to progesterone Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117155	212670
Ensembl	ENSG00000166762	ENSMUSG00000033486
UniProt	Q96P56	A2ARP9
RefSeq (mRNA)	NM_001282309 NM_001282310 NM_054020 NM_172095 NM_172097	NM_153075
RefSeq (protein)	NP_001269238.1 NP_473361.1 NP_742093.1	n/a
Location (UCSC)	Chr 15: 43.63 – 43.67 Mb	Chr 2: 121.39 – 121.41 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene. CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636. 
• Garbers DL (2001). "Ion channels. Swimming with sperm.". Nature. 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929. 
• Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa.". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.