Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4gene. The protein encoded by this gene is a chloride channel.[3] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[4]
^Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID10437792.
^Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID16470849.
Ritzka M, Stanke F, Jansen S, et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID15490240.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2000). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID11071307.
. PMID 10758170.
